ACTRN12618001958279尚未招募2 期
Defining the Novel Effects of Mineralocorticoid Receptor Antagonism on Metabolism in Humans – A Randomised Controlled Trial
Dr Moe Thuzar0 个研究点目标入组 32 人开始时间: 2018年12月4日最近更新:
适应症
试验速览
- 阶段
- 2 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 32
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 18 Years 至 45 Years（—）
- 性别
- Female
入选标准
- •BMI 25-40 kg/m2
排除标准
- •(i) estimated glomerular filtration rate (eGFR) less than 60 ml/min
- •(ii) serum potassium more than 5mmol/L in a non-haemolysed blood sample
- •(iii) thyroid or endocrine dysfunction
- •(iv) significant organ dysfunction such as heart failure, liver failure
- •(v) active malignancy
- •(vi) pregnant or planning pregnancy
- •(vii) unable to provide informed consent
- •(viii) alcohol intake >14 standard drinks per week or smoking
- •(ix) Unable to maintain stable diet and lifestyle during the study period
- •(x) taking medications that may interact with spironolactone or have effect on metabolism such as anti-hypertensives acting on the renin-angiotensin or sympathetic system, diuretics, anti-diabetic medications, corticosteroids, anti-psychotics
研究者
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