Efficacy, Safety and Immunological Evaluation of Upadacitinib for Relapsing Polychondritis

Phase 1

Recruiting

• Conditions: Relapsing Polychondritis
• Interventions: Drug: Upadacitinib; Drug: corticosteroids and immunosuppressants

• Registration Number: NCT06873100
• Lead Sponsor: Peking University People's Hospital

Brief Summary

Relapsing polychondritis (RP) is a rare, systemic autoimmune disorder characterized by episodic inflammation of cartilaginous structures.

The goal of this clinical trial is to learn if drug Upadacitinib works to treat relapsing polychondritis in adults. It will also learn about the safety of drug Upadacitinib. The main questions it aims to answer are:

* Does drug Upadacitinib reduce the disease activity of relapsing polychondritis?

* What medical problems do participants have when taking drug Upadacitinib? Researchers will compare drug Upadacitinib to conventional therapies (treatment with corticosteroids combined with immunosuppressants) to see if drug Upadacitinib works to treat relapsing polychondritis.

Participants will:

* Take drug Upadacitinib or corticosteroids combined with immunosuppressants every day for 24 weeks.

* Visit the hospital once every month for checkups and tests. This clinical study will explore the efficacy and immunological evaluation of Upadacitinib in the treatment of RP.

Detailed Description

Not available

Study Timeline

• Status Verified: 2024-10
• Study Start: 2024-11-15
• Study First Submitted: 2025-02-26
• Study First Submitted QC: 2025-03-06
• Last Update Submitted: 2025-03-06
• Study First Posted: 2025-03-12
• Last Update Posted: 2025-03-12
• Primary Completion: 2026-08-01
• Study Completion: 2026-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• 1.Male or female ≥18 and ≤70 years
• 2.Meet the revised Michet criteria
• 3.Patients had an inadequate response to standard treatment for ≥ 4 weeks. The background treatment included corticosteroids (≤0.5 mg/ kg), immunosuppressants ( methotrexate, hydroxychloroquine, azathioprine, mycophenolate mofetil leflunomide, or cyclophosphamide)
• 4. Negative urine pregnancy test
• 5. Written informed consent form

Exclusion Criteria

Any subject who meets any of the following criteria shall be excluded:

• 1.Use rituximab or other monoclonal antibodies within 2 months.
• 2.1 months after treatment with high dose glucocorticoid (> 1 mg/kg/d).
• 3.Serious complications: heart failure (≥ New York Heart Association（NYHA） III grade), renal insufficiency (creatinine clearance rate ≤ 30 ml/min), liver function insufficiency (serum alanine transaminase or glutamic-pyruvic transaminaseT > 3 times normal upper limit, or total bilirubin > normal upper limit)
• 4.Other serious, progressive or uncontrollable hematological, gastrointestinal, endocrine, lung, heart, nerve, or brain diseases (including demyelination diseases, such as multiple sclerosis).
• 5.Known allergies, hyperresponsiveness or IL-2 or its excipients are intolerant.
• 6.Severe infections (including, but not limited to, hepatitis, pneumonia, bacteremia, pyelonephritis, Epstein-Barr virus, tuberculosis infection), hospitalization for infection, or intravenous antibiotics 2 months before the first dose of treatment.
• 7.Chest imaging showed abnormalities in malignant tumors or current active infections (including tuberculosis) within 3 months before the first use of the study.
• 8.Infected with HIV (HIV antibody positive serology) or hepatitis C (Hep C antibody positive serology). If seropositive, consult a doctor with expertise in the treatment of HIV or hepatitis C virus infection.
• 9.There has been any known malignant tumor or history of malignant tumor in the past 5 years (with the exception of non-melanoma skin cancer, non-melanoma skin cancer with no sign of recurrence or surgically cured cervical tumor within 3 months of use of the first study preparation).
• 10.There are uncontrolled mental or emotional disorders, including a history of drug and alcohol abuse over the past three years, which may hinder the successful completion of the study. 11.Within 3 months before the first injection of the research agent, during the study period or within 4 months after the last injection of the research agent, any live virus or bacterial vaccine is received or expected to be received. Bacillus Calmette-Guerin was vaccinated within 12 months after screening.
• 11.Pregnant and lactating women (WCBP) are reluctant to use medically approved contraceptives during and 12 months after treatment.
• 12.Men whose partners have fertility potential but do not want to use appropriate medically approved contraceptives during and within 12 months of treatment.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Experimental Group	Upadacitinib	-
Countrol Group	corticosteroids and immunosuppressants	-

Primary Outcome Measures

Name	Time	Method
CRP variation	24 weeks	Modification of inflammatory makers

Secondary Outcome Measures

Name	Time	Method
Relapsing Polychondritis Disease Activity Index	24 weeks
Variation of lymphocyte subpopulations and cytokine during the treatment of upadacitinib	24 weeks	Cytokine and lymphocyte subgroups of T cell, B cell and NK cell are analyzed during the treatment.
Improvement of clinical symptom measured by 5-level EQ-5D version (EQ-5D-5L)	24 weeks	The EQ-5D-5L is a health-related quality-of-life instrument developed by the EuroQol Group. It is designed to measure health status across five dimensions: mobility, self-care, usual activities, pain/discomfort, and anxiety/depression. Each dimension has five response levels: no problems, slight problems, moderate problems, severe problems, and extreme problems.
Alteration of inflammatory biomarkers and pathways after treatment of upadacitinib	24 weeks	We will investigate the potential pathways through which Upadacitinib exerts its effects and examine the changes in inflammatory biomarkers during the experimental process
Incidence of Treatment-Emergent Adverse Events	24 weeks	Adverse events includes influenza-like symptoms, infection, fever, tumor,drug-induced liver and kidney damage.

Trial Locations

Locations (1)

Department of Rheumatology and Immunology, Peking University People's Hospital; 🇨🇳 Beijing, Beijing, China