Bed-rest, Muscle Mass and Insulin Sensitivity

Not Applicable

Completed

• Conditions: Disuse Atrophy

• Registration Number: NCT02109380
• Lead Sponsor: Maastricht University Medical Center

Brief Summary

In the present study, the effects of 7 days of bed rest on muscle mass, muscle fiber characteristics and insulin sensitivity will be determined.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2014-04-01
• Study First Submitted QC: 2014-04-04
• Study First Posted: 2014-04-09
• Study Start: 2014-06
• Status Verified: 2015-04
• Primary Completion: 2015-04
• Last Update Submitted: 2015-04-27
• Last Update Posted: 2015-04-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 15

Inclusion Criteria

• Male
• Aged from 18-35 years
• 18.5 < BMI < 30 kg/m2

Exclusion Criteria

• Smoking
• Performing regular resistance training (3+ times per week, carrying out progressive training) in the previous 6 months
• Hypertension (according to WHO criteria) and/or cardiovascular disease
• Any back/leg/knee/neck/postural complaints
• Use of any prescribed medication
• Type 2 diabetes mellitus
• Any family history of thrombosis
• All co-morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthritis, spasticity/rigidity, all neurological disorders and paralysis).
• Myocardial infarction within the last 3 years
• Use of anti-coagulants

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Change in quadriceps muscle cross-sectional area	One day before and directly after cessation of bed rest.

Secondary Outcome Measures

Name	Time	Method
Change in muscle strength	One day before and directly after cessation of bed rest.	Measured by 1-Repetition Maximum testing
Change in lower back cross-sectional area	One day before and directly after cessation of bed rest.
Change in leg and whole body lean tissue mass	One day before and directly after cessation of bed rest.
Change in muscle fiber size	One day before and directly after cessation of bed rest.
Change in insulin sensitivity	One day before and directly after cessation of bed rest.	Measured by hyperinsulinemic-euglycemic clamp

Trial Locations

Locations (1)

Maastricht University Medical Centre; 🇳🇱 Maastricht, Netherlands