NCT02109380已完成不适用
The Impact of Short-term Bed-rest on Skeletal Muscle Mass and Insulin Sensitivity in Healthy, Young Men
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 15
- 试验地点
- 1
- 主要终点
- Change in quadriceps muscle cross-sectional area
研究概览
简要总结
In the present study, the effects of 7 days of bed rest on muscle mass, muscle fiber characteristics and insulin sensitivity will be determined.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Aged from 18-35 years
- •18.5 < BMI < 30 kg/m2
排除标准
- •Performing regular resistance training (3+ times per week, carrying out progressive training) in the previous 6 months
- •Hypertension (according to WHO criteria) and/or cardiovascular disease
- •Any back/leg/knee/neck/postural complaints
- •Use of any prescribed medication
- •Type 2 diabetes mellitus
- •Any family history of thrombosis
- •All co-morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthritis, spasticity/rigidity, all neurological disorders and paralysis).
- •Myocardial infarction within the last 3 years
- •Use of anti-coagulants
结局指标
主要结局
Change in quadriceps muscle cross-sectional area
时间窗: One day before and directly after cessation of bed rest.
次要结局
- Change in muscle strength(One day before and directly after cessation of bed rest.)
- Change in lower back cross-sectional area(One day before and directly after cessation of bed rest.)
- Change in leg and whole body lean tissue mass(One day before and directly after cessation of bed rest.)
- Change in muscle fiber size(One day before and directly after cessation of bed rest.)
- Change in insulin sensitivity(One day before and directly after cessation of bed rest.)
研究者
Lex Verdijk
Assistant Professor
Maastricht University Medical Center
研究点 (1)
Loading locations...
相似试验
已完成
不适用
The impact of short-term bed-rest on skeletal muscle mass and insulin sensitivity in healthy, young meNL-OMON41776Medisch Universitair Ziekenhuis Maastricht10
招募中
不适用
The Impact of Bed Rest, Aging and NMES on Skeletal MuscleDisuse Atrophy (Muscle) of Lower ExtremitiesMuscle FunctionNeuromuscular Electrical StimulationMyofibrillar Protein SynthesisNCT05617222Bispebjerg Hospital32
招募中
Unknown
The effect of sleep quality on skeletal muscle mass in healthy adultshealthy adultsJPRN-UMIN000051098Health Sciences University of Hokkaido20
已完成
不适用
Effects of Unloading on Muscle MassImmobilizationPhysical InactivityNCT00936039Maastricht University Medical Center15
已完成
不适用
Timecourse of Immobilization ExperimentMuscular AtrophyNCT02984332University of Exeter13