Effects of Unloading on Muscle Mass

Not Applicable

Completed

• Conditions: Immobilization; Physical Inactivity
• Interventions: Behavioral: unloading

• Registration Number: NCT00936039
• Lead Sponsor: Maastricht University Medical Center

Brief Summary

In the present study, the effects of 3 weeks of unloading on muscle mass and muscle fiber characteristics will be determined. In addition, the effects of 6 weeks of recovery will be assessed.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2009-07-06
• Study First Submitted QC: 2009-07-08
• Study First Posted: 2009-07-09
• Study Start: 2009-10
• Primary Completion: 2013-02
• Study Completion: 2013-06
• Status Verified: 2013-07
• Last Update Submitted: 2013-07-01
• Last Update Posted: 2013-07-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 15

Inclusion Criteria

• Healthy
• BMI < 30 kg/m2

Exclusion Criteria

• Use of medication that may affect haemostasis
• Subjects with (recent) musculoskeletal/orthopaedic disorders known to affect the outcome of the study or that compromise their ability to walk with crutches
• Subjects with metal implants in their lower limbs
• Subjects with known cardiovascular and/or haemostasis disorders
• Subjects with known severe hypertension

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
unloading	unloading	2 weeks of unloading

Primary Outcome Measures

Name	Time	Method
muscle mass, muscle fiber size	1 week before unloading; immediately (1 day) after unloading and 6 weeks after unloading

Secondary Outcome Measures

Name	Time	Method
muscle strength	1 week before unloading; immediately (1 day) after unloading and 6 weeks after unloading

Trial Locations

Locations (1)

Maastricht University Medical Centre; 🇳🇱 Maastricht, Netherlands