The Effect of Aging and Immobilisation on Muscle
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- muscle cross sectional area, maximal isometric muscle strength, specific force, muscle fascicle length and muscle fibre pennation
研究概览
简要总结
The debilitating effects of immobilisation on muscle strength and size in young individuals are well documented. Moreover, sarcopenia has long been recognized as a major cause of muscle strength loss in old age, however, changes in muscle mass and architecture with immobilisation in the elderly has not previously been investigated. This is contrasted by the fact that the elderly population more often undergoes periods of immobilization and disuse not only due to joint pain but also due to a higher degree of co morbidity and hospitalisation.The purpose of the present study was to compare the effect of a 2 week period of unilateral immobilisation on the physiological muscle cross sectional area, maximal isometric muscle strength, specific force, muscle fascicle length and muscle fibre pennation angle in young and old healthy men.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Young healthy males (age 20-30 yrs)or old healthy males (age 60-80 yrs)
排除标准
- •Musculoskeletal disorder
- •Cardiovascular disease
- •Neurological diseases; or
- •Cognitive disorders
结局指标
主要结局
muscle cross sectional area, maximal isometric muscle strength, specific force, muscle fascicle length and muscle fibre pennation
时间窗: 2 weeks of immobilisation and 4 weeks of resistance training
次要结局
- single muscle fiber area, expression of myostatin and IGF-1 (RNA), changes in satellite activation and number(2 weeks of imm and 4 weeks of resistance training)