The Genetic variability in the host response to community-acquired pneumonia

Completed

Conditions: lower respiratory tract infection
pneumonia
10004018
10024970

Registration Number: NL-OMON35629

Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 2000

Inclusion Criteria

1.Age of 18 years of older
2.Admission to the hospital
3.Community-acquired pneumonia defined as:
a.New or progressive infiltrate on a chest X-ray and
b.2 of the following criteria:
-Cough
-sputum production
-dyspnea
-rectal temperature > 38oC or < 36.1oC
-ausculatory findings consistent with pneumonia
-leucocytosis (>10.000/mm3, or >15% bands)
-C-reactive protein > 3 times the upper limit of normal
4. A least three grandparents form Dutch origin

Exclusion Criteria

1.Hospitalization for more than >=48h in the 2 weeks prior to enrollment in the study
2.Infections other than pneumonia that need immediate treatment
3.Life expectancy < 2 months

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1.To identify genetics variations associated with the genetic risk of<br /><br>susceptibility to community-acquired pneumonia.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>1.To identify genetic variations associated with a severe community-acquired<br /><br>pneumonia on admission. Pneumonia severity will be determined by (a) mortality<br /><br>of community-acquired pneumonia within 24 hours; (b) Pneumonia severity scores:<br /><br>Pneumonia Severity Index and CURB-65 score (appendix 4) and (c) Location of<br /><br>treatment after first survey in ER (ward versus ICU).<br /><br><br /><br>2.To indentify genetic variations associated with poor response to treatment:<br /><br>determined by (a) development of complications during hospitalization (b)<br /><br>mortality after first day and within 30 days of admission. (c) admission to ICU<br /><br>during hospitalization. </p><br>