Type 2 Diabetes Affect Exercise Induced Improvement in Insulin Sensitivity

Not Applicable

Completed

• Conditions: Insulin Sensitivity/Resistance
• Interventions: Other: 8 weeks of combined exercise intervention

• Registration Number: NCT02745613
• Lead Sponsor: University of Texas, El Paso

Brief Summary

This study investigates weather a family history of type 2 diabetes affects exercise induced improvements in insulin sensitivity in the hispanic population

Detailed Description

A family history of T2D (FH+) is a risk factor for developing insulin resistance (which precedes T2D) and T2D (Ryder et al., 2003). Exercise training on the other hand has been shown to improve insulin sensitivity and is highly effective to prevent/manage T2D. However it is not known if early signs of insulin resistance appear before being clinically diagnosed and if the benefits of exercise which prevent/cure T2D, are limited to the offspring of Hispanic T2D parents. Therefore, the proposed study will determine 1) if normoglycemic (normal blood glucose) offspring of T2D parents are insulin resistant, using the gold standard method to measure insulin sensitivity and metabolic flexibility (ability to switch between carbohydrate and fat oxidation) 2) if 8 weeks of exercise training improves insulin sensitivity and metabolic flexibility to the same extent in FH+ compared to normoglycemic offspring of parents without any history of T2D (FH-) and 3) if 8 weeks of exercise training will change the blood, lipid and molecular profiles relevant to insulin sensitivity to same extent in FH+ compared to offspring of parents without family history of T2D (FH-).

Study Timeline

• Study Start: 2016-04
• Study First Submitted: 2016-04-18
• Study First Submitted QC: 2016-04-19
• Study First Posted: 2016-04-20
• Primary Completion: 2019-05
• Study Completion: 2019-05
• Status Verified: 2020-01
• Last Update Submitted: 2020-01-28
• Last Update Posted: 2020-01-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 24

Inclusion Criteria

• 18 ≤ Age ≤ 40 years
• 18 ≤ BMI ≤ 30 kg/m2
• Both parents are Mexican/Mexican-American)
• Sedentary lifestyle
• Less than 60 minutes/wk. of structured exercise
• Physical activity level ≤ 1.4

Exclusion Criteria

• Evidence of significant cardiovascular disease or diabetes
• A fasting blood glucose ≥100 mg/dL
• Screening blood pressure >140/90
• Hyperlipidemia
• Use of drugs affecting energy metabolism or body weight
• Excess alcohol, drug abuse, and smoking
• Eating disorder or eating attitudes interfering with study
• Unwillingness to be abide by randomization

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Family history of T2D	8 weeks of combined exercise intervention	The participants will undergo 8 weeks of combined exercise
No Family history of T2D	8 weeks of combined exercise intervention	The participants will undergo 8 weeks of combined exercise

Primary Outcome Measures

Name	Time	Method
Insulin sensitivity	8 weeks

Secondary Outcome Measures

Name	Time	Method
Myokine concentrations	8 weeks

Trial Locations

Locations (1)

University of Texas at El Paso; 🇺🇸 El Paso, Texas, United States