Does a Family History of Type 2 Diabetes Affect Exercise Induced Improvement in Insulin Sensitivity?
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- Insulin sensitivity
研究概览
简要总结
This study investigates whether: (i) a family history of type 2 diabetes affects exercise induced improvements in insulin sensitivity. (ii) being prediabetic affects exercise induced improvements in glycemic control. (iii) sex differences affect exercise induced improvements in glycemic control.
详细描述
A family history of T2D (FH+) is a risk factor for developing insulin resistance (which precedes T2D) and T2D (Ryder et al., 2003). Exercise training on the other hand has been shown to improve insulin sensitivity and is highly effective to prevent/manage T2D. However it is not known if early signs of insulin resistance appear before being clinically diagnosed and if the benefits of exercise which prevent/cure T2D, are limited to the offspring of Hispanic T2D parents. Therefore, the proposed study will determine 1) if normoglycemic (normal blood glucose) offspring of T2D parents are insulin resistant, using the gold standard method to measure insulin sensitivity and metabolic flexibility (ability to switch between carbohydrate and fat oxidation) 2) if 8 weeks of exercise training improves insulin sensitivity and metabolic flexibility to the same extent in FH+ compared to normoglycemic offspring of parents without any history of T2D (FH-) and 3) if 8 weeks of exercise training will change the blood, lipid and molecular profiles relevant to insulin sensitivity to same extent in FH+ compared to offspring of parents without family history of T2D (FH-). This study will also determine how differently individuals with prediabetes response to exercise compared to those with normal glucose and further investigate sex differences in cardiometabolic response to exercise training.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Health Services Research
- 盲法
- Double (Care Provider, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Sedentary/moderately active lifestyle
- •Less than 150 minutes/wk. of structured exercise
- •Physical activity level ≤ 1.4
排除标准
- •Evidence of significant cardiovascular disease
- •Screening blood pressure >140/90
- •Pregnancy or breastfeeding
- •Use of drugs affecting energy metabolism or body weight
- •Excess alcohol, drug abuse, and smoking
- •Eating disorder or eating attitudes interfering with study
- •Excessively or active individuals
- •Unwillingness to abide by randomization
- •Injury that prevents the performance of exercise
研究组 & 干预措施
Family history of T2D
The participants will undergo 8 weeks of combined exercise
干预措施: 8 weeks of combined exercise intervention (Other)
No Family history of T2D
The participants will undergo 8 weeks of combined exercise
干预措施: 8 weeks of combined exercise intervention (Other)
结局指标
主要结局
Insulin sensitivity
时间窗: 8 weeks
Insulin sensitivity
时间窗: 8-weeks
Insulin sensitivity will be measured hyperinsulinemic -euglycemic clamp
Glycemic control (long term)
时间窗: 8-weeks
Glycated hemoglobin (HbA1c) will be measured from whole blood with a bench top chemistry analyzer
Glycemic control (postprandial)
时间窗: 8-weeks
Postprandial glycemic control will be measured by an oral glucose tolerance test (OGTT)
Glycemic variability
时间窗: 8-weeks
Glycemic variability will be assessed with glucose monitoring
次要结局
- Myokine concentrations(8 weeks)
- Cellular mitochondria function(8-weeks)
- Cytokines(8-weeks)
- Blood gene expression markers of glycemic control(8-weeks)
- Peripheral blood mononuclear cell (PBMC) markers of glucose metabolism(8-weeks)
研究者
Sudip Bajpeyi
Professor
University of Texas, El Paso