a clinical trial to study the effects of three drugs, dexmedetomedine, ketamine and tramadol for prevention of shivering under spinal anaesthesia
Phase 4
- Conditions
- Health Condition 1: M179- Osteoarthritis of knee, unspecified
- Registration Number
- CTRI/2020/12/029892
- Lead Sponsor
- Dr Tanwin Khan
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 120
Inclusion Criteria
Patientâ??s undergoing elective surgery under spinal anaesthesia and with valid consent
ASA-1 and 2
Age 18-65 yrs
Height â?? 140- 180cms
Lower limb surgeries
Lower abdominal surgeries
Exclusion Criteria
Patient refusal
ASA- 3 & 4
Age < 18yrs & > 65yrs
Drug allergy
Compromised cardio- respiratory functions
Renal or hepatic disease
Thyroid disorders
Psychiatric disorder
Severe diabetes or autonomic neuropathies
Known history of substance or alcohol abuse
Pregnant patients
Obese (body mass index >30kg/m2)
Contraindications to spinal anaesthesia
Patients having visual analogue scale (VAS) >6 intra-operatively and were offered general anaesthesia
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method All the drugs i.e, dexmedetomedine, ketamine and tramadol decrease the shivering under spinal anesthesia compared to normal saline in their lowest possible doses used <br/ ><br> <br/ ><br>Timepoint: wrench shivering grades 1 and 2 are managed conservatively and grades 3 and 4 are treated with pethidine <br/ ><br>
- Secondary Outcome Measures
Name Time Method side effects of drugs dexmedetomidine(sedation), ketamine(increased arterial blood pressure) and tramadol(nausea and vomitings) are studiedTimepoint: sedation is assessed with filos grading and grade 3 and 4 are considered positive