MagnetoEncephaloGraphy Study of Cerebral Activations Induced by Psychomotor Tasks for Target Localisation in View of BCI Clinical Trial
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 37
- 试验地点
- 2
- 主要终点
- MEG records for functional brain mapping
研究概览
简要总结
The study aims at mapping the magnetoencephalographic (MEG) activities induced in normal volunteers by tapping the finger .
详细描述
Normal healthy (20) volunteers and tetraplegic patients(10) will be submitted to the temporo-spatial mapping of their brain activity, both sensory and motor, induced by a simple behavioral task, consisting on tapping with the finger on a detection pad. This will be done in a light and then dark environment, on a rythm spontaneous and then paced by sound bips. Accelerometric recording will provide the three dimensionnal displacements of the finger as well as the time code.
Brain activity is simultaneously recorded using MEG (306 channels) and EEG (64 channels. Data will be processed by an INPLS algorithm to detect the predictors of activity, their location and time-course.
3D mapping data will be matched with the patient's anatomy provided by 1.5T MRI previously performed.
The aim of the study is to prepare the strategy of implantation of multielectrodes ECoG implants to restore motility in tetraplegic patients in a human BCI protocol currently under development.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Male or Female between 18 and 70 years
- •Informed consent
- •Benefiting from Social Security
- •French or english speaking, to understand study procedure
- •Tetraplegic patients : traumatic injury of the cervical spine with retained respiratory autonomy and without associated head injury
排除标准
- •Contra-indication to MRI
- •Claustrophobia
- •Mental disorders
- •All categories of protected persons
结局指标
主要结局
MEG records for functional brain mapping
时间窗: one hour study
This study is not a therapeutic clinical study. No treatment is being delivered.
次要结局
- MEG measurements during psychomotor tasks(one hour study)
- EEG measurements during psychomotor tasks(one hour study)