Effects of Different Sports Supplements on Metabolism and Perceptual Responses During Distance Running

Not Applicable

Terminated

• Conditions: Anomalies Gastrointestinal
• Interventions: Dietary Supplement: Placebo Beverage; Dietary Supplement: Carbohydrate Beverage

• Registration Number: NCT03596788
• Lead Sponsor: Old Dominion University

Brief Summary

Several previous studies have shown that repeatedly ingesting carbohydrate supplements during exercise training sessions, over a period of days and weeks, can gradually increase carbohydrate oxidation and reduce gut discomfort during exercise. However, repeatedly ingesting large amounts of carbohydrate during training sessions can be burdensome and can cause gut distress. Thus, it would be advantageous if the same long-term benefits could be realized from consuming these carbohydrate supplements at rest instead of specifically during training sessions. Therefore, the goal of this study is to examine whether repeatedly ingesting a carbohydrate-rich beverage at rest over a 5-day period alters metabolism and gut symptoms while ingesting carbohydrate during exercise.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2018-06-28
• Study First Submitted QC: 2018-07-12
• Study First Posted: 2018-07-24
• Study Start: 2018-08-01
• Primary Completion: 2025-02-17
• Study Completion: 2025-02-17
• Status Verified: 2025-03
• Last Update Submitted: 2025-03-17
• Last Update Posted: 2025-03-20

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 4

Inclusion Criteria

• Be currently running ≥15 miles per week
• Have completed at least one run >60 minutes over the past month
• Have completed one or more marathons within the past year

Exclusion Criteria

• Overt cardiovascular disease or metabolic disorder
• Adverse symptoms (e.g., unusual shortness of breath, dizziness, chest pain) with exercise
• Allergies/intolerances to any of the ingredients in the beverages

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Placebo Beverage	Placebo Beverage	An artificially-sweetened beverage containing aspartame
Carbohydrate Beverage	Carbohydrate Beverage	A glucose-fructose beverage mixture supplying 100 grams of carbohydrate per day for 5 days

Primary Outcome Measures

Name	Time	Method
Change in Hydrogen Breath Production	Samples will be collected before after a 60-minute run at a baseline visit and at a second visit after ingesting the carbohydrate or placebo beverage for 5 days.	Samples of expired air will be tested for hydrogen levels, a marker of carbohydrate malabsorption
Change in Gastrointestinal Symptom Ratings	Symptoms will be collected during a 60 minute run on a treadmill at a baseline visit and at a second visit after ingesting the carbohydrate or placebo beverage for 5 days.	Symptoms such as nausea, fullness, belching, reflux, abdominal cramps, flatulence, and urge to defecate will be recorded on a 0-10 scale (0 = no discomfort, 10 = unbearable discomfort).

Secondary Outcome Measures

Name	Time	Method
Change in Feeling Scale	Ratings will be collected collected before and during each 60-minute run at a baseline visit and at a second visit after ingesting the carbohydrate or placebo beverage for 5 days.	A bipolar scale ranging from -5 (very bad) to +5 (very good)
Change in Carbohydrate Oxidation	Respiratory gases will be collected during each 60-minute run at a baseline visit and at a second visit after ingesting the carbohydrate or placebo beverage for 5 days.	Respiratory gases will be used to estimate carbohydrate oxidation rates.

Trial Locations

Locations (1)

Human Performance Lab; 🇺🇸 Norfolk, Virginia, United States