Evaluation of Motor-Related Beta-Activity in Relation to Naturalistic Movement in Healthy Adult Subjects
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 31
- 试验地点
- 2
- 主要终点
- Timing of beta bursts in motor cortex, measured with MEG before initiation of a movement
研究概览
简要总结
The whole body's voluntary movements are controlled by the brain. One of the brain areas most involved in controlling these voluntary movements is the motor cortex and it is often viewed as the primary 'output' region of the neocortex. Motor cortical activity in the beta frequency range (13-30Hz) is a hallmark signature of healthy and pathological movement, but its behavioral relevance remains unclear. Such uncertainty confounds the development of treatments for diseases of movement which are associated with pathophysiological beta activity, including Parkinson's, therefore furthering understanding on the behavioral significance of activity in this range is now vital. Recently, it has become apparent that oscillatory beta activity actually occurs in discrete transient bursts, and that the summation of short-lasting, high-powered bursts of activity only appear to be sustained oscillations when averaged over multiple trials.
In this study we will use neurophysiological and neuroimaging techniques such as electroencephalography (EEG), magnetoencephalography (MEG), and magnetic resonance imaging (MRI). All of these techniques have been identified as non-invasive techniques. By applying these methods, we will be able to analyze beta burst activity in order to determine how beta bursts influence naturalistic motor behavior.
This project also encompasses the study of auditory and motor interactions doing an experimental task.
The aim of the project is to get a better understanding of the role of motor-related beta activity during the preparation and generation of reach and grasp actions. These findings may inform novel treatments for pathophysiological disorders characterized by aberrant beta signaling, utilizing causal manipulation of the neural circuits implicated in the generation of beta activity. This project also has expected methodological repercussions. It will make it possible to validate the use of individualized head-casts worn during MEG acquisition for the study of the cortical control of naturalistic actions, and to create new analysis tools that allow an increase in the spatial resolution of MEG data.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •For all experiments :
- •Healthy male or female
- •Aged 18-40 years
- •Registered with the French healthcare system
- •Motivated to participate in the study
- •Normal or corrected vision
- •Right-handed
- •Adequate knowledge of French to be able to follow directions
- •Subjects must have the minimal motor ability necessary to participate in the experiment
- •Subjects must be able to listen and understand the study instructions
- •Subjects must be able to give written informed consent before participation
- •Normal hearing
排除标准
- •For all experiments :
- •Subjects with characteristics incompatible with MEG/EEG and MRI :
- •Claustrophobia
- •Psychiatric pathology characterized including Alzheimer's disease, Parkinson's disease, multiple sclerosis (MS), or severe traumatic brain injury
- •Neuropsychological disorders or cognitive impairment including schizophrenia, bipolar disorder, seizures, epilepsy, sleep disorders
- •Regular use of neurodevelopment medicines (antidepressants, neuroleptics)
- •Subject has a history of skin disease or skin allergies (multiple or severe)
- •Subject working with metals in their professional lives
- •The subject had an MRI 2 weeks prior to experiment 1
- •Implanted material (any dental apparatus containing metal including or root canals or any metallic object, pacemaker, cochlear implanted in the body)
- •Pregnant women or lactating women (based on self-report)
- •subjects who are not able to tolerate sitting for 1 hour (the estimated length of the experiment)
- •Alcohol dependence
- •Subjects who, in the opinion of the investigator are not able or willing to comply with the protocol
- •For experiment 1:
- •A head size incompatible with the use of a personalized 3D head-cast or a magnetoencephalography
结局指标
主要结局
Timing of beta bursts in motor cortex, measured with MEG before initiation of a movement
时间窗: The data of subjects will be collected and analyzed through study completion an average of 2 years
Timing (ms, relative to motion onset) of beta bursts in motor cortex with MEGthan the one planned is cued and must be performed.
Spatial location of beta bursts in motor cortex, measured with MEG before initiation of a movement
时间窗: The data of subjects will be collected and analyzed through study completion an average of 2 years
Spatial location (mm, in a brain-centered reference frame) of beta bursts in motor cortex, measured with MEG
Timing of beta bursts in motor cortex, measured with EEG before initiation of a movement
时间窗: The data of subjects will be collected and analyzed through study completion an average of 2 years
Timing (ms, relative to motion onset) of beta bursts in motor cortex with EEG
Spatial location of beta bursts in motor cortex, measured with EEG before initiation of a movement
时间窗: The data of subjects will be collected and analyzed through study completion an average of 2 years
Spatial location (mm, in a brain-centered reference frame) of beta bursts in motor cortex, measured with EEG
次要结局
- Timing of beta bursts in motor cortex, measured with MEG before initiation of a movement(The data of subjects will be collected and analyzed through study completion an average of 2 years)
- Spatial location of beta bursts in motor cortex, measured with MEG before initiation of a movement(The data of subjects will be collected and analyzed through study completion an average of 2 years)
- Timing of beta bursts in motor cortex, measured with EEG before initiation of a movement(The data of subjects will be collected and analyzed through study completion an average of 2 years)
- Visual stimuli(The data of subjects will be collected and analyzed through study completion an average of 2 years.)
- Spatial location of beta bursts in motor cortex, measured with EEG before initiation of a movement(The data of subjects will be collected and analyzed through study completion an average of 2 years)
- Beta amplitude, measured with MEG(The data of subjects will be collected and analyzed through study completion an average of 2 years)
- Beta amplitude, measured with EEG(The data of subjects will be collected and analyzed through study completion an average of 2 years)
- Within-session movement(The data of subjects will be collected and analyzed through study completion an average of 2 years.)
- Auditory stimuli(The data of subjects will be collected and analyzed through study completion an average of 2 years.)
- Determine what aspects of grasp kinematics can be decoded from beta burst activity in motor cortex and related regions.(The data of subjects will be collected and analyzed through study completion an average of 2 years.)