Staged Nutrition and Activity Counselling (SNAC) interventions that prime targeted antihypertensive therapy to prevent cardiovascular outcomes in the primary care setting
Completed
- Conditions
- High-normal blood pressure and/or impaired glucose regulation.Circulatory SystemHypertension
- Registration Number
- ISRCTN42921300
- Lead Sponsor
- awson Health Research Institute (Canada)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 300
Inclusion Criteria
1. Men and women aged 40 - 85 years who are able to provide informed consent
2. Presence of high-normal blood pressure, impaired fasting glucose, impaired glucose tolerance, or all of them
Exclusion Criteria
1. Unstable cardiovascular or metabolic disease
2. Previous diagnosis of hypertension or type 2 diabetes
3. Myocardial infarction, coronary artery bypass, or cerebrovascular ischaemia/stroke (including Transient Ischaemic Attack [TIA]) within 3 months prior to study
4. History of alcoholism, drug abuse, or other emotional, cognitive or psychiatric problems that are likely to limit compliance to the study
5. Pacemaker
6. Already enrolled in a clinical research trial
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Improvements in exercise capacity, left ventricular diastolic function (E/A ratio), and brachial artery endothelial function, measured at V1 - V5 (see interventions).
- Secondary Outcome Measures
Name Time Method 1. Caloric profile and anthropometrics, measured at V1 - V5 (see interventions)<br>2. Resting blood pressure and 24-hour ambulatory blood pressure, measured at V1 - V5<br>3. Blood chemistries (glucose, lipids, catecholamines, HbA1c, etc), measured at V1 - V5<br>4. Muscle sympathetic nerve activity, measured at V1 - V5<br>5. Geometry and elastic properties of the carotid artery, and geometry of left ventricle, measured at V1 - V5