Analisi Della Perdita di Forza e Potenza Muscolare e Del Degrado Del Controllo Motorio Per la Predizione Delle Cadute in Una Popolazione Affetta da Artrosi di Ginocchio
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Knee Osteoarthritis (Knee OA)
- Sponsor
- Istituto Ortopedico Rizzoli
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- Muscle volumes
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
The twofold goal of this study is to understand the link between muscle power, muscle strength, and muscle control degradation with the risk of falling, and to develop a framework for the comprehensive and quantitative assessment of muscle power (and strength) in an elderly population of patients with knee osteoarthritis, who are at higher risk of falling. The main question it aims to answer is:
● Are muscle power and motor control degradation better predictors of falls than muscle strength in the aging population?
Participants will undergo:
- Muscle force assessment on a dynamometer
- Muscle power assessment on a dynamometer and on isntrumented stairs
- Home-based mobility monitoring
- Full lower limb MRI acquisition
- Gait assessment
Detailed Description
Falls are a critical yet common event among the elderly, with huge societal and economic impact (reduced quality of life and high costs for the healthcare system). Experimental measures to quantify the residual muscle strength and power may provide useful information to predict the risk of falls in the elderly. Isometric and isokinetic muscle contractions, performed on a dynamometer or during functional tasks can be collected, together with electromyography (to assess muscle activity) and imaging data (to quantify and characterize muscular tissue). Such data can be collected at different time points to monitor subjects over time, and to inform virtual representation of the human musculoskeletal system (digital twins) to identify possible motor control deficits. Moreover, this same information can be used to better characterize/assess elder individuals at risk of falling (e.g., subjects with knee osteoarthritis), to prevent future falls. All subjects enrolled in the PowerAGING study will be followed up for 24 months (5 visits in total: M0, M6, M12, M18 and M24 follow-up). At each visit, a series of experimental tests to quantify muscle power and muscle force, as well as a home-based mobility assessment (via single inertial sensor worn for 5 consecutive days), will be performed. In addition, only at start and end, the subjects will undergo a full lower limb MRI and a gait assessment.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Age between 65 and 80 years
- •Kellgren score II e III
- •No history of falls in the last 12 months
Exclusion Criteria
- •Any musculoskeletal, neurological, rheumatic or tumoral diseases
- •Inguinal or abdominal hernia
- •Severe Hypertension (Level 3)
- •Severe Cardio-pulmonary insufficiency
- •Diagnosis of Osteonecrosis in the lower limb joints
- •Pathologies or physical conditions incompatible with the use of magnetic resonance imaging and electrostimulation (i.e., active and passive implanted biomedical devices, epilepsy, severe venous insufficiency in the lower limbs)
- •Previous interventions or traumas to the joints of the lower limb
Outcomes
Primary Outcomes
Muscle volumes
Time Frame: From baseline (Day 0) to last visit (Month 24)
Maximal muscle force
Time Frame: At baseline (Day 0) and all follow-up visits (Month 6, Month 12, Month 18, Month 24)
Maximal Isometric muscle force from dynamometry test
Muscle activations
Time Frame: At baseline (Day 0) and all follow-up visits (Month 6, Month 12, Month 18, Month 24)
From surface EMG data collected on the dynamometer and during dynamic tasks (gait assessment and stair ascent/descent)
Muscle power
Time Frame: At baseline (Day 0) and all follow-up visits (Month 6, Month 12, Month 18, Month 24)
Assessed on the dynamometer and during dynamic tasks
Digital Mobility Outcomes
Time Frame: At baseline (Day 0) and all follow-up visits (Month 6, Month 12, Month 18, Month 24)
Qualitative and quantiative measures of real-world mobility (e.g., gait speed, stride length)
Musculoskeletal model predictions
Time Frame: At baseline (Day 0) and all follow-up visits (Month 6, Month 12, Month 18, Month 24)
Estimates of muscle force and knee joint contact forces