Effect of intravenous Lidocaine bolus on the median effective concentration (EC50) of Propofol during target controlled infusion (TCI : Schnider model) for gastroscopy in adult patients : a prospective, randomized, double-blinded study

Hopital Erasme0 个研究点目标入组 50 人开始时间: 2023年12月14日最近更新: 2024年7月22日

适应症

试验速览

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•All patients having to benefit from gastroscopy under narcosis at the ERASME hospital, Age between 18-65 years, ASA score I or II (American Society of Anesthesiologists), Body mass index (BMI) between 18 and 30 kg/m2, Knowledge of French / French speakers, Signed written informed consent

•Any allergy or contraindication to one or more of the substances used, Pregnant or breast-feeding at the time of the study, History of intoxication by local anesthetics, Indication for oro-tracheal intubation, Emergency gastroscopy, Pre-gastroscopy premedication, Chronic consumption of powerful analgesics / drug addiction, Psychiatric disorder, Epilepsy, Severe renal failure (GFR < 30 ml/min/1.73m2), History of malignant hyperthermia, Severe liver failure, Blood coagulation disorders, Anticoagulant medication, Upper lung infection, Mitochondrial disease, Drug interaction with Propofol and/or Lidocaine: concomitant use of Rifampicine, Valproate, Phenytoin, Cardiac glycosides (Digoxin), Class III antiarrhythmics (Amiodarone), Cimetidine, Barbiturates, Isoprenaline, Glucagon, Cardiac arrhythmia (bradycardia < 50/min, atrioventricular block II-III, severe sino-atrial block), Severe heart failure (LVEF < 30%), Obesity (BMI > 30 kg/m2), Proven sleep apnea syndrome or suspected sleep apnea syndrome with STOP-BANG score > 5, Have undergone local anesthesia within the previous 24 hours or general anesthesia within the previous 7 days, Methemoglobinemia, Porphyria

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