Comparison Between Pregabalin and Magnesium Sulfate in Hypotensive Anaesthesia

Phase 1

• Conditions: Functional Endoscopic Sinus Surgery
• Interventions: Drug: Pregabalin 150mg; Drug: Magnesium Sulfate; Drug: Nitroglycerin; Other: surgeon satisfaction

• Registration Number: NCT05442931
• Lead Sponsor: Minia University

Brief Summary

Comparison between pregabalin and magnesium sulfate in hypotensive anaethesia

Detailed Description

compare the effect of a single-dose 150 mg oral pregabalin and 2 grams intravenous magnesium sulfate given 30 minutes before induction of anesthesia on the total nitroglycerine used in patients undergoing functional endoscopic sinus surgery

Study Timeline

• Study First Submitted: 2022-03-25
• Study Start: 2022-05-01
• Status Verified: 2022-06
• Study First Submitted QC: 2022-06-28
• Last Update Submitted: 2022-06-28
• Study First Posted: 2022-07-05
• Last Update Posted: 2022-07-05
• Primary Completion: 2022-10-30
• Study Completion: 2022-10-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• ASA: class 1 or 2
• Sex: male and female
• Age: from 18 to 70 years
• Patients scheduled for functional endoscopic sinus surgery

Exclusion Criteria

• Patient on diuretics, corticosteroid, pregabalin
• Patients with a history of allergy to the study drug
• Pregnancy or breastfeeding women Patients with hypertension, cardiac, renal endocrinal diseases
• uncooperative patients (cant does not administer oral tablet)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Pregabaline	Pregabalin 150mg	Preoperative oral dose of pregabalin for control blood pressure and decrease dose of nitroglycerine consumption
Nitroglycrine	surgeon satisfaction	Measuring the total dose of nitroglycerine used, using a syringe pump
Magnesium sulfate	Magnesium Sulfate	Preoperative intravenous dose for control blood pressure and heart rate
Nitroglycrine	Nitroglycerin	Measuring the total dose of nitroglycerine used, using a syringe pump

Primary Outcome Measures

Name	Time	Method
Dose of nitroglycerine	an hour and half	total dose measured by a syringe pump

Secondary Outcome Measures

Name	Time	Method
quality of surgical field	an hour and half	using Boezaart et al grading scale
surgeon satisfaction	an hour and half	using Likert's scale

Trial Locations

Locations (1)

Faculty of medicine; 🇪🇬 Minya, Egypt