The effect of exercise during radiotherapy on tumour oxygenation to improve treatment effectiveness in prostate cancer patients

Not Applicable

Recruiting

• Conditions: Prostate cancer; Cancer - Prostate; Physical Medicine / Rehabilitation - Other physical medicine / rehabilitation

• Registration Number: ACTRN12620000432910
• Lead Sponsor: Edith Cowan University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-04-01
• Last Update Posted: 21 February 2022

Recruitment & Eligibility

• Status: Recruiting
• Sex: Male
• Target Recruitment: 30

Inclusion Criteria

Men diagnosed with localised or locally advanced prostate cancer who are scheduled to receive radiotherapy.

Exclusion Criteria

(1) Previous or concomitant surgery or treatment for prostate cancer, except androgen deprivation therapy
(2) Distant metastases
(3) Contraindications to exercise training at moderate to vigorous intensity
(4) Baseline activity levels of >150 min/week at moderate to vigorous intensity
(5) Any uncontrolled medical condition
(6) Body mass index (BMI) >35 kg/m2
(7) Contraindication to magnetic resonance imaging or contrast agent
(8) Inability to walk 400 meters uninterrupted, unassisted, and pain-free

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Tumour perfusion as assessed by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI)[Baseline, 48 hours after baseline MRI, and following completion of radiotherapy at 6-8 weeks];Tumour hypoxia as assessed by serological analysis of hypoxia-inducible factor 1-alpha (HIF-1alpha)[Baseline and following the completion of radiotherapy at 6-8 weeks];Tumour hypoxia as assessed by serological analysis of carbonic anhydrase 9 (CAIX)[Baseline and following the completion of radiotherapy at 6-8 weeks]