Comparison of the ability of the brain to adapt to change and its relation to genetic differences in patients with schizophrenia and depression as seen in brain stimulation tests and brain imaging tests.
- Conditions
- Health Condition 1: F332- Major depressive disorder, recurrent severe without psychotic featuresHealth Condition 2: F322- Major depressive disorder, singleepisode, severe without psychotic featuresHealth Condition 3: F20- Schizophrenia
- Registration Number
- CTRI/2022/12/048536
- Lead Sponsor
- Ashok Jammigumpula
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Schizophrenia
Schizophrenia (according to DSM 5) with persisting symptoms
Score of >=4 on one or more of the items of BPRS
4 (conceptual disorganization)
11 (suspiciousness)
12 (hallucinatory behaviour)
15 (unusual thought content)
OR
A score of >=12 on all the above items combined
Right-handed in accordance with the Edinburgh Handedness Inventory
Speak either Kannada or English
Written informed consent
Depression
Major Depressive Disorder (according to DSM 5) with persisting symptoms
HAMD-17 score >=18
Right-handed in accordance to the Edinburgh Handedness Inventory
Speak either Kannada or English
Written informed consent
Healthy Controls
Matched for age, gender and education
Right-handed in accordance to the Edinburgh Handedness Inventory
Speak either Kannada or English
Written informed consent
Schizophrenia
Any history of other major psychiatric disorders
Neurological disorders associated with movement impairments
SUD in the last six months (except nicotine)
Pregnancy
Any contraindication to HD-tDCS or TMS
Depression
Any history of other major psychiatric disorders
Neurological disorders associated with movement impairments
Bipolar depression
Psychotic disorder or symptoms
SUD in the last six months (except nicotine)
Pregnancy
Any contraindication to HD-tDCS or TMS
Healthy Controls
Any history of major psychiatric disorders
SUD in the last six months (except nicotine)
Neurological disorders associated with movement impairments
Major psychiatric illnesses in first-degree relatives
Pregnancy
Any contraindication to HD-tDCS or TMS
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method