on-Alcoholic Fatty Liver Disease: non-invasive diagnosis with MR Elastography and MR Spectroscopy

• Conditions: accumulation of fat in the liver; non-alcoholic fatty liver disease; 10019654

• Registration Number: NL-OMON34446
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 60

Inclusion Criteria

- Patients over 18 years of age
- Patients with biopsy-proven NAFLD/NASH or with suspected NALFD/NASH who are scheduled for liver biopsy.
- Liver biopsy < 6 weeks ago or liver biopsy performed within 6 weeks after MRI
- Written informed consent

Exclusion Criteria

- Patients under 18 years of age
- Alcohol consumption of >3 units per dag for males and >2 units per day for females
- Patients with contra-indications for MRI (use of standard MRI checklist)
- Patients with extreme obesity (will not fit in the MRI)

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>* Elasticity values (kPa) for simple steatosis group vs. NASH group<br /><br>* Viscosity values (kPa*s) for simple steatosis group vs. NASH group<br /><br>* Liver fat content (% of liver volume) for simple steatosis group vs. NASH<br /><br>group<br /><br>* FibroScan measurement (kPa) for simple steatosis group vs. NASH group</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>n.a.</p><br>