on Alcoholic Fatty Liver Disease (NAFLD) and Small Intestinal Bacterial Overgrowth (SIBO)

Recruiting

Conditions: Small Intestinal Bacterial Overgrowth
K76.0
K75.8
K90.2
Fatty (change of) liver, not elsewhere classified
Other specified inflammatory liver diseases
Blind loop syndrome, not elsewhere classified

Registration Number: DRKS00009875

Lead Sponsor: Hepatogastroenterology Unit, Second Department of Internal Medicine and Research Institute, Attikon University General Hospital, Medical School, Athens University

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 60

Inclusion Criteria

Enrolled patients (Arm1) should have radiological and/or biochemical and/or histological evidence of fatty liver.
Healthy controls (Arm 2) consist of participants that undergo upper gastrointestinal endoscopy in terms of dyspepsia investigation and have no evidence of any liver disease.
Cirrhotic controls (Arm 3) consist of patients with cirrhosis of any etiology.

Exclusion Criteria

1. Age <18 years
2. Ongoing alcohol overconsumption
3. Recent use of antibiotics (within the last 3 months)
4. Recent upper gastrointestinal bleeding
5. Inability to provide informed consent
Additionally for the Patient Group:
1. Absence of any other liver related disease (viral hepatitis, metabolic liver diseases, hepatocellular carcinoma)

Study & Design

Study Type: observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
• Compare SIBO prevelance in patients between NAFLD patients, healthy controls and cirrhotics using duodenal aspirate culture, breath test and qrt-PCR

Secondary Outcome Measures

Name	Time	Method
• Detecte a possible correlation between M. Smithii presence in small intestine and NAFLD/NASH using breath test and qrt-PCR.<br>• Determine the total bacterial count and M. Smithii count in feces with the use of qrt-PCR.<br>• Investigate a potential correlation of SIBO with the risk factors of NAFLD development.<br>• Determine the role of inflammatory process in NAFLD pathogenesis. <br>