Effect of Physiological Ischemic Training on Patients With Atherosclerosis

Not Applicable

Recruiting

• Conditions: Atherosclerosis
• Interventions: Behavioral: exercise

• Registration Number: NCT05091762
• Lead Sponsor: Nanjing First Hospital, Nanjing Medical University

Brief Summary

To study whether the resistance training with blood flow obstruction in patients in early atherosclerosis period can produce a beneficial effect on preventing atherosclerosis.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2021-09-23
• Status Verified: 2021-10
• Study Start: 2021-10-12
• Study First Submitted QC: 2021-10-20
• Last Update Submitted: 2021-10-20
• Study First Posted: 2021-10-25
• Last Update Posted: 2021-10-25
• Primary Completion: 2025-12-31
• Study Completion: 2025-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

1. LDL > 3.11mmol/l and less than 5.63mmol/l;
2. No serious heart, blood vessel and other related diseases;
3. There were no skeletal and muscular diseases affecting sports training;
4. No regular exercise in the past half year (no more than 2 times a week, no more than 30 minutes each time);
5. Smoking less than 1 pack / year, no history of drinking.

Exclusion Criteria

1. Haven't other serious heart and vascular diseases other than hyperlipidemia and / or bones and muscles that affect sports training Diseases;
2. Pregnant women and people with disabilities;
3. Other circumstances determined by the researcher not suitable for the study.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Hyperlipidemia and medication and exercise group	exercise	-
Hyperlipidemia and exercise group	exercise	-
Exercise group	exercise	-
Routine treatment and exercise group	exercise	-

Primary Outcome Measures

Name	Time	Method
Endothelium dependent vasodilation	8 weeks	Percentage of the change
Blood lipid analysis results	8 weeks	Content of total cholesterol, triglycerides, high density lipoprotein and low density lipoprotein

Secondary Outcome Measures

Name	Time	Method
Endothelial repair function	8 weeks	eNOSmRNA, iNOSmRNA, EPCs in blood
The inflammatory state	8 weeks	Content of NO, eNOS, iNOS, IFN-γ, IL-6, IL-10 in blood

Trial Locations

Locations (1)

Nanjing First Hospital; 🇨🇳 Nanjing, Jiangsu, China