Efficacy Evaluation Study of Vitamin C and Glutathione Liquid Sachet
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- The change of skin tone
研究概览
简要总结
The objective of this study is to evaluate the effect of liquid vitamin C and glutathione supplements on human skin condition improvement and anti-oxidation.
详细描述
This study is a single-center, placebo-controlled, double-blinded, parallel human trial designed to evaluate the skin beauty and anti-oxidant effect of liquid vitamin C and glutathione supplements.
Healthy adult participants aged 18-65 years will be enrolled. Participants will be informed to consume test samples daily for 12 consecutive weeks. Skin measurement and self-assessment questionnaires will be conducted at baseline (before intake), after 4, 8 weeks, and 12 weeks of consumption. Fasting blood samples will be collected at baseline and after 12 weeks of consumption.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy male or female adults, aged 18-65 years old;
- •Commitment not to use products having activity comparable with that of the product to be tested during the study period;
- •Free of any dermatological or systemic disorder that would interfere with results.
排除标准
- •Subject with obvious skin surface damage;
- •Subject who had oral or topical medication which may affect skin condition within 1 month;
- •Individuals with known allergies to cosmetics, medications, or foods (especially those allergic to legumes/soy);
- •Pregnant or breastfeeding individuals;
- •Received facial laser therapy, chemical peeling in the past 2 months.
- •Individuals unwilling to allow publication or public disclosure of photographs taken as part of the study results
研究组 & 干预措施
Placebo sachet
干预措施: Placebo sachet (Dietary Supplement)
Vitamin C and Glutathione Liquid Sachet
干预措施: Vitamin C and Glutathione Liquid Sachet (Dietary Supplement)
结局指标
主要结局
The change of skin tone
时间窗: Change from Baseline skin tone at 12 weeks
Chroma Meter MM500 was utilized to measure face skin tone. Units: Individual Typology Angle (ITA°)
The change of visible spots
时间窗: Change from Baseline visible spots at 12 weeks
VISIA Complexion Analysis was utilized to measure visible spots on face. Units: the amount of detectable visible spots
The change of UV spots
时间窗: Change from Baseline UV spots at 12 weeks
VISIA Complexion Analysis was utilized to measure UV spots on face. Units: the amount of detectable UV spots
次要结局
- The change of skin hydration(Change from Baseline skin hydration at 12 weeks)
- The change of skin redness(Change from Baseline skin redness at 12 weeks)
- The change of skin melanin index(Change from Baseline skin melanin index at 12 weeks)
- The change of skin elasticity(Change from Baseline skin elasticity at 12 weeks)
- The change of brown spots(Change from Baseline brown spots at 12 weeks)
- The change of wrinkles around the eyes(Change from Baseline wrinkles around the eyes at 12 weeks)
- The change of skin texture(Change from Baseline skin texture at 12 weeks)
- The change of skin collagen density(Change from Baseline skin collagen density at 12 weeks)
- The change of total antioxidation capacity (TAC)(Change from Baseline TAC at 12 weeks)
- The change of Superoxide Dismutase (SOD)(Change from Baseline SOD at 12 weeks)
- The change of Glutathione S-transferase-Red Blood Cells (GST-RBC)(Change from Baseline GST-RBC at 12 weeks)
- The change of Malondialdehyde (MDA)(Change from Baseline MDA at 12 weeks)