A Study to Evaluate Patient Preference for Home Administration of Fixed-Dose Combination of Pertuzumab and Trastuzumab for Subcutaneous Administration in Participants With Early or Locally Advanced/Inflammatory HER2-Positive Breast Cancer
- Conditions
- Early Breast CancerLocally Advanced Breast CancerInflammatory Breast Cancer
- Interventions
- Drug: Investigator's Choice of ChemotherapyProcedure: SurgeryRadiation: Radiotherapy
- Registration Number
- NCT05415215
- Lead Sponsor
- Hoffmann-La Roche
- Brief Summary
This is a Phase IIIb, multinational, multicenter, randomized, open-label study to evaluate patient preference of the fixed-dose combination of pertuzumab and trastuzumab for subcutaneous use (PH FDC SC) administration in the home setting compared with the hospital setting during the cross-over period of adjuvant treatment in participants with early or locally advanced/inflammatory human epidermal growth factor receptor 2-positive (HER2+) breast cancer.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 347
- Eastern Cooperative Oncology Group (ECOG) performance status 0-1
- Intact skin at planned site of subcutaneous (SC) injections
- Left ventricular ejection fraction (LVEF) greater than or equal to (≥)55% by echocardiogram (ECHO) or multiple-gated acquisition scan (MUGA)
- Negative human immunodeficiency virus (HIV) test at screening
- Negative hepatitis B surface antigen (HBsAg) test at screening
- Positive hepatitis B surface antibody (HBsAb) test at screening, or negative HBsAb at screening accompanied by either of the following: Negative total hepatitis B core antibody (HBcAb); Positive total HBcAb test followed by a negative (per local laboratory definition) hepatitis B virus (HBV) DNA test
- Negative hepatitis C virus (HCV) antibody test at screening, or positive HCV antibody test followed by a negative HCV RNA test at screening
- For female participants of childbearing potential: agreement to remain abstinent or use contraception and agree to refrain from donating eggs during the treatment period and for 7 months after the final dose of the study treatment
- For male participants: agreement to remain abstinent or use a condom, and agree to refrain from donating sperm during the treatment period and for 7 months after the final dose of study treatment
Disease-specific Inclusion Criteria:
- Female and male participants with stage II-IIIC early or locally advanced/inflammatory human epidermal growth factor receptor 2-positive (HER2+) breast cancer
- Primary tumor >2 centimetres (cm) in diameter, or node-positive disease
- HER2+ breast cancer confirmed by a local laboratory prior to study enrollment. HER2+ status will be determined based on pretreatment breast biopsy material and defined as 3+ by Immunohistochemistry (IHC) and/or positive by HER2 amplification by in situ hybridization (ISH) following American Society of Clinical Oncology (ASCO)/College of American Pathologists (CAP) guidelines 2018 and updates (Wolff et al. Arch Pathol Lab Med 2018)
- Hormone receptor status of the primary tumor determined by local assessment following American Society of Clinical Oncology (ASCO)/College of American Pathologists (CAP) guidelines and updates (Allison et al. J Clin Oncol 2020)
- Agreement to undergo mastectomy or breast conserving surgery after neoadjuvant therapy, including the axillary nodes
- Availability of formalin-fixed, paraffin-embedded (FFPE) tumor tissue block for local confirmation of HER2 and hormone receptor status following current ASCO/CAP guidelines
Inclusion Criteria for Treatment with Adjuvant PH FDC SC:
- Completed the neoadjuvant phase of this study and underwent surgery, and achieved pathologic complete response (pCR), defined as eradication of invasive disease in the breast and axilla according to the current American Joint Committee on Cancer (AJCC) staging system classification, and using the resected specimen by the local pathologist on the basis of guidelines to be provided in a pathology manual
- Adequate wound healing after breast cancer surgery per investigator's assessment to allow initiation of study treatment within less than or equal to (≤)9 weeks of last systemic neoadjuvant therapy
- Stage IV (metastatic) breast cancer
- History of concurrent or previously treated non-breast malignancies, except for appropriately treated 1) non-melanoma skin cancer and/or 2) in situ carcinomas, including cervix, colon, and skin. A participant with previous invasive non-breast cancer is eligible provided he/she has been disease free for more than 5 years
- Participants who are pregnant or breastfeeding or intending to become pregnant during the study or within 7 months after the final dose of study treatments
- Treatment with investigational therapy within 28 days prior to initiation of study treatment
- Active, unresolved infections at screening requiring treatment
- Participants who may have had a recent episode of thromboembolism and are still trying to optimize the anticoagulation dose and/or have not normalized their International Normalized Ratio (INR)
- Serious cardiac illness or medical conditions
- History of ventricular dysrhythmias or risk factors for ventricular dysrhythmias
- Inadequate bone marrow function
- Impaired liver function
- Renal function with creatinine clearance <50 mL/min using the Cockroft-Gault formula and serum creatinine >1.5x upper limit of normal (ULN)
- Major surgical procedure unrelated to breast cancer within 28 days prior to study entry or anticipation of the need for major surgery during the course of study treatment
- Current severe, uncontrolled systemic disease that may interfere with planned treatment
- Any serious medical condition or abnormality in clinical laboratory tests that precludes an individual's safe participation in and completion of the study
- Treatment with a live vaccine (e.g., FluMist) in the 30 days prior to initiation of study treatment, or anticipation of need for such a vaccine during treatment or within 90 days after the final dose of study treatment
- Known active liver disease, for example, active viral hepatitis infection, autoimmune hepatic disorders, or sclerosing cholangitis
- Known hypersensitivity to any of the study drugs, excipients, and/or murine proteins or a history of severe allergic or immunological reactions, e.g., difficult to control asthma
- Current chronic daily treatment with corticosteroids
- Assessment by the investigator as being unable or unwilling to comply with the requirements of the protocol
Cancer-specific Exclusion Criteria for Neoadjuvant Phase:
- Participants who have received any previous systemic therapy for treatment or prevention of breast cancer, or previous chest irradiation for the treatment of cancer
- Participants who have a past history of ductal carcinoma in situ (DCIS) or lobular carcinoma in situ (LCIS) if they have received any systemic therapy for its treatment or radiation therapy to the ipsi- or contralateral breast cancer
- Participants with high-risk for breast cancer who have received chemopreventive drugs in the past
- Participants with multicentric breast cancer, unless all tumors are HER2+
- Participants with bilateral breast cancer
- Participants who have undergone an excisional biopsy of primary tumor and/or axillary lymph nodes
- Axillary lymph node dissection (ALND) prior to initiation of neoadjuvant therapy
- Sentinel lymph node biopsy (SLNB) prior to neoadjuvant therapy
Exclusion Criterion for Treatment with Adjuvant Trastuzumab Emtansine (Arm E):
- Current Grade ≥3 peripheral neuropathy (according to the NCI CTCAE v5.0)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Arm A: Pertuzumab IV and Trastuzumab IV Plus Investigator's Choice of Chemotherapy Trastuzumab IV During the neoadjuvant phase, the enrolled participants randomized to this arm will receive treatment with pertuzumab and trastuzumab intravenously (PH IV) plus investigator's choice of chemotherapy (Option 1, 2, or 3). With chemotherapy Option 1, PH IV will be administered at each cycle from Cycles 1 to 6 (1 cycle is 3 weeks); with chemotherapy Options 2 and 3, PH IV will be administered once per cycle from Cycles 5 to 8 (1 cycle is 3 weeks). Arm A: Pertuzumab IV and Trastuzumab IV Plus Investigator's Choice of Chemotherapy Pertuzumab IV During the neoadjuvant phase, the enrolled participants randomized to this arm will receive treatment with pertuzumab and trastuzumab intravenously (PH IV) plus investigator's choice of chemotherapy (Option 1, 2, or 3). With chemotherapy Option 1, PH IV will be administered at each cycle from Cycles 1 to 6 (1 cycle is 3 weeks); with chemotherapy Options 2 and 3, PH IV will be administered once per cycle from Cycles 5 to 8 (1 cycle is 3 weeks). Arm A: Pertuzumab IV and Trastuzumab IV Plus Investigator's Choice of Chemotherapy Investigator's Choice of Chemotherapy During the neoadjuvant phase, the enrolled participants randomized to this arm will receive treatment with pertuzumab and trastuzumab intravenously (PH IV) plus investigator's choice of chemotherapy (Option 1, 2, or 3). With chemotherapy Option 1, PH IV will be administered at each cycle from Cycles 1 to 6 (1 cycle is 3 weeks); with chemotherapy Options 2 and 3, PH IV will be administered once per cycle from Cycles 5 to 8 (1 cycle is 3 weeks). Arm A: Pertuzumab IV and Trastuzumab IV Plus Investigator's Choice of Chemotherapy Surgery During the neoadjuvant phase, the enrolled participants randomized to this arm will receive treatment with pertuzumab and trastuzumab intravenously (PH IV) plus investigator's choice of chemotherapy (Option 1, 2, or 3). With chemotherapy Option 1, PH IV will be administered at each cycle from Cycles 1 to 6 (1 cycle is 3 weeks); with chemotherapy Options 2 and 3, PH IV will be administered once per cycle from Cycles 5 to 8 (1 cycle is 3 weeks). Arm A: Pertuzumab IV and Trastuzumab IV Plus Investigator's Choice of Chemotherapy Radiotherapy During the neoadjuvant phase, the enrolled participants randomized to this arm will receive treatment with pertuzumab and trastuzumab intravenously (PH IV) plus investigator's choice of chemotherapy (Option 1, 2, or 3). With chemotherapy Option 1, PH IV will be administered at each cycle from Cycles 1 to 6 (1 cycle is 3 weeks); with chemotherapy Options 2 and 3, PH IV will be administered once per cycle from Cycles 5 to 8 (1 cycle is 3 weeks). Arm B: PH FDC SC Plus Investigator's Choice of Chemotherapy Investigator's Choice of Chemotherapy During the neoadjuvant phase, the enrolled participants randomized to this arm will receive treatment with the fixed dose combination of pertuzumab and trastuzumab for subcutaneous use (PH FDC SC) plus investigator's choice of chemotherapy (Option 1, 2, or 3). With chemotherapy Option 1, PH FDC SC will be administered at each cycle from Cycles 1 to 6 (1 cycle is 3 weeks); with chemotherapy Options 2 and 3, PH FDC SC will be administered once per cycle from Cycles 5 to 8 (1 cycle is 3 weeks). Arm B: PH FDC SC Plus Investigator's Choice of Chemotherapy Surgery During the neoadjuvant phase, the enrolled participants randomized to this arm will receive treatment with the fixed dose combination of pertuzumab and trastuzumab for subcutaneous use (PH FDC SC) plus investigator's choice of chemotherapy (Option 1, 2, or 3). With chemotherapy Option 1, PH FDC SC will be administered at each cycle from Cycles 1 to 6 (1 cycle is 3 weeks); with chemotherapy Options 2 and 3, PH FDC SC will be administered once per cycle from Cycles 5 to 8 (1 cycle is 3 weeks). Arm B: PH FDC SC Plus Investigator's Choice of Chemotherapy Radiotherapy During the neoadjuvant phase, the enrolled participants randomized to this arm will receive treatment with the fixed dose combination of pertuzumab and trastuzumab for subcutaneous use (PH FDC SC) plus investigator's choice of chemotherapy (Option 1, 2, or 3). With chemotherapy Option 1, PH FDC SC will be administered at each cycle from Cycles 1 to 6 (1 cycle is 3 weeks); with chemotherapy Options 2 and 3, PH FDC SC will be administered once per cycle from Cycles 5 to 8 (1 cycle is 3 weeks). Arm E: Adjuvant Trastuzumab Emtansine Trastuzumab Emtansine Participants with pathological evidence of residual invasive carcinoma in the breast or axillary lymph nodes following completion of preoperative therapy and surgery will enter Arm E to receive trastuzumab emtansine for 14 cycles. Trastuzumab emtansine will be administered IV in the hospital as per prescribing information. Arm B: PH FDC SC Plus Investigator's Choice of Chemotherapy Fixed Dose Combination of Pertuzumab and Trastuzumab for Subcutaneous Use (PH FDC SC) During the neoadjuvant phase, the enrolled participants randomized to this arm will receive treatment with the fixed dose combination of pertuzumab and trastuzumab for subcutaneous use (PH FDC SC) plus investigator's choice of chemotherapy (Option 1, 2, or 3). With chemotherapy Option 1, PH FDC SC will be administered at each cycle from Cycles 1 to 6 (1 cycle is 3 weeks); with chemotherapy Options 2 and 3, PH FDC SC will be administered once per cycle from Cycles 5 to 8 (1 cycle is 3 weeks). Arm C: Adjuvant PH FDC SC in Hospital, Then at Home Fixed Dose Combination of Pertuzumab and Trastuzumab for Subcutaneous Use (PH FDC SC) During the adjuvant phase, participants who have achieved pCR after surgery will be treated with 2 cycles of PH FDC SC in the hospital (run-in period). After completion of the last cycle of radiotherapy and the last cycle of PH FDC SC (run-in period), participants will then be randomized with a ratio of 1:1 into one of two treatment arms (Arm C or D) in a cross-over treatment period to receive the next 6 cycles of PH FDC SC treatment. Participants in Arm C will receive 3 cycles of PH FDC SC in the hospital and then 3 cycles of PH FDC SC in the home setting. After the cross-over treatment period, participants will receive the remaining PH FDC SC treatment cycles required to complete the planned 18 cycles of HER2-directed therapy, unless of disease recurrence, unacceptable toxicity, or withdrawal. Study treatment during this treatment continuation period will be administered either in the hospital or in the home setting as selected by the participant at the end of the crossover period. Arm D: Adjuvant PH FDC SC at Home, Then in Hospital Fixed Dose Combination of Pertuzumab and Trastuzumab for Subcutaneous Use (PH FDC SC) During the adjuvant phase, participants who have achieved pCR after surgery will be treated with 2 cycles of PH FDC SC in the hospital (run-in period). After completion of the last cycle of radiotherapy and the last cycle of PH FDC SC (run-in period), participants will then be randomized with a ratio of 1:1 into one of two treatment arms (Arm C or D) in a cross-over treatment period to receive the next 6 cycles of PH FDC SC treatment. Participants in Arm D will receive 3 cycles of PH FDC SC in the home setting and then 3 cycles of PH FDC SC in the hospital. After the cross-over treatment period, participants will receive the remaining PH FDC SC treatment cycles required to complete the planned 18 cycles of HER2-directed therapy, unless of disease recurrence, unacceptable toxicity, or withdrawal. Study treatment during this treatment continuation period will be administered either in the hospital or in the home setting as selected by the participant at the end of the crossover period.
- Primary Outcome Measures
Name Time Method Percentage of Participants Who Preferred the Administration of PH FDC SC in the Home Setting Compared With the Hospital Setting, Question 1 of the Patient Preference Questionnaire Day 1 of Cycle 8 of adjuvant treatment (1 cycle is 3 weeks)
- Secondary Outcome Measures
Name Time Method Percentage of Healthcare Professionals by Their Responses on Perception of Time/Resource Use of Each Study Regimen, Questions 3 and 4 of the HCPQ - Neoadjuvant Phase Drug Preparation Area Day 1 of last cycle (Cycle 6 or 8) of neoadjuvant treatment (1 cycle is 3 weeks) Percentage of Healthcare Professionals by Their Responses on Perception of Impact of PH FDC SC on Clinical Management and Clinical Efficiency, Question 2 of the HCPQ - Neoadjuvant Phase Administering Treatment Day 1 of last cycle (Cycle 6 or 8) of neoadjuvant treatment (1 cycle is 3 weeks) Percentage of Healthcare Professionals by Their Responses on Perception of Time/Resource Use and Convenience of Each Study Regimen, Questions 3 to 10 of the HCPQ - Neoadjuvant Phase Administering Treatment Day 1 of last cycle (Cycle 6 or 8) of neoadjuvant treatment (1 cycle is 3 weeks) Duration of Treatment Preparation, According to Healthcare Professionals' Responses to Question 1 of the Healthcare Professional Questionnaire (HCPQ) - Neoadjuvant Phase Drug Preparation Area Day 1 of each cycle from first cycle (Cycle 1 or 5) to last cycle (Cycle 6 or 8) of PH IV or PH FDC SC neoadjuvant treatment (1 cycle is 3 weeks) Percentage of Healthcare Professionals by Their Responses on Perception of Impact of PH FDC SC on Clinical Management and Clinical Efficiency, Question 2 of the HCPQ - Neoadjuvant Phase Drug Preparation Area Day 1 of last cycle (Cycle 6 or 8) of neoadjuvant treatment (1 cycle is 3 weeks) Health-Related Quality of Life Assessed by the European Organization for Research and Treatment of Cancer Core Quality of Life (EORTC QLQ)-C30 Questionnaire Scores in the Neoadjuvant Phase Day 1 of Cycle 1 and Day 1 of last cycle of neoadjuvant treatment (Cycle 6 or 8; 1 cycle is 3 weeks) Health-Related Quality of Life Assessed by the EORTC QLQ-C30 Questionnaire Scores in Participants Treated with PH FDC SC During the Adjuvant Phase Day 1 of Cycles 1, 3, 5, 8, and last cycle of adjuvant treatment (1 cycle is 3 weeks) Duration of Treatment Administration Activities, According to Healthcare Professionals' Responses to Question 1 of the HCPQ - Neoadjuvant Phase Administering Treatment Day 1 of each cycle from first cycle (Cycle 1 or 5) to last cycle (Cycle 6 or 8) of PH IV or PH FDC SC neoadjuvant treatment (1 cycle is 3 weeks) Percentage of Healthcare Professionals by Their Responses on Perception of Time/Resource Use in the Home and Hospital Settings, Questions 3 to 6 of the HCPQ - Adjuvant Phase Administering Treatment Day 1 of Cycle 8 of adjuvant treatment (1 cycle is 3 weeks) Percentage of Healthcare Professionals by Their Responses to Question 7 of the HCPQ - Adjuvant Phase Administering Treatment Day 1 of Cycle 8 of adjuvant treatment (1 cycle is 3 weeks) Percentage of Healthcare Professionals by Their Responses to Question 11 of the HCPQ - Neoadjuvant Phase Administering Treatment Day 1 of last cycle (Cycle 6 or 8) of neoadjuvant treatment (1 cycle is 3 weeks) Percentage of Participants Achieving Pathologic Complete Response (pCR) Post-surgery (up to 27 weeks) pCR is defined as eradication of invasive disease in the breast and axilla (i.e., ypT0/Tis ypN0), according to local pathologist assessment following the American Joint Committee on Cancer (AJCC) criteria.
Health-Related Quality of Life Assessed by the EORTC QLQ-C30 Questionnaire Scores in Participants Treated with Trastuzumab Emtansine During the Adjuvant Phase Day 1 of Cycles 1, 7, and 14 of adjuvant treatment (1 cycle is 3 weeks) Duration of Treatment Preparation, According to Healthcare Professionals' Responses to Question 1 of the HCPQ - Adjuvant Phase Drug Preparation Area Day 1 of Cycles 5 and 8 of adjuvant treatment (1 cycle is 3 weeks) Percentage of Healthcare Professionals by Their Responses on Perception of the Treatment Setting's Impact on Clinical Management and Clinical Efficiency, Question 2 of the HCPQ - Adjuvant Phase Drug Preparation Area Day 1 of Cycle 8 of adjuvant treatment (1 cycle is 3 weeks) Percentage of Healthcare Professionals by Their Responses on Perception of Time/Resource Use in the Home and Hospital Settings, Questions 3 and 4 of the HCPQ - Adjuvant Phase Drug Preparation Area Day 1 of Cycle 8 of adjuvant treatment (1 cycle is 3 weeks) Incidence of Premature Withdrawal from Adjuvant Treatment with PH FDC SC From Cycle 1 to last cycle (Cycle 12 or 14) of adjuvant treatment (1 cycle is 3 weeks) Incidence of Premature Withdrawal from Adjuvant Treatment with Trastuzumab Emtansine From Cycle 1 to Cycle 14 (last cycle; 1 cycle is 3 weeks) Number of Participants with Clinical Laboratory Test Abnormalities During the Adjuvant Treatment Phase From first dose post-surgery until the last dose of adjuvant treatment (up to 1.5 years) Number of Participants with Vital Sign Abnormalities During the Adjuvant Treatment Phase From first dose post-surgery until the last dose of adjuvant treatment (up to 1.5 years) Duration of Treatment Administration Activities, According to Healthcare Professionals' Responses to Question 1 of the HCPQ - Adjuvant Phase Administering Treatment Day 1 of Cycles 5 and 8 of adjuvant treatment (1 cycle is 3 weeks) Number of Participants with Clinical Laboratory Test Abnormalities During the Neoadjuvant Treatment Phase From Baseline until surgery (up to 27 weeks) Number of Participants with at Least One Adverse Event During the Adjuvant Treatment Phase, with Severity Determined According to the NCI CTCAE v5.0 From first dose post-surgery up to 9 months after the last dose of adjuvant treatment (up to 2 years) Percentage of Healthcare Professionals by Their Responses on Perception of the Treatment Setting's Impact on Clinical Management and Clinical Efficiency, Question 2 of the HCPQ - Adjuvant Phase Administering Treatment Day 1 of Cycle 8 of adjuvant treatment (1 cycle is 3 weeks) Percentage of Participants who Selected the Administration of PH FDC SC in the Home Setting Compared With the Hospital Setting in the Treatment Continuation Period Day 1 of Cycle 8 of adjuvant treatment (1 cycle is 3 weeks) Number of Participants with at Least One Adverse Event During the Neoadjuvant Treatment Phase, with Severity Determined According to the National Cancer Institute Common Terminology Criteria for Adverse Events, version 5.0 (NCI CTCAE v5.0) From Baseline until surgery (up to 27 weeks) Incidence of Premature Withdrawal from Neoadjuvant Treatment with PH FDC SC or Pertuzumab IV and Trastuzumab IV From Cycle 1 to last cycle (Cycle 6 or 8) of neoadjuvant treatment (1 cycle is 3 weeks) Number of Participants with Vital Sign Abnormalities During the Neoadjuvant Treatment Phase From Baseline until surgery (up to 27 weeks)
Trial Locations
- Locations (90)
Centro Oncologico Korben
🇦🇷Ciudad Autonoma Buenos Aires, Argentina
Cantonal Hospital Zenica
🇧🇦Zenica, Bosnia and Herzegovina
Hospital Araujo Jorge
🇧🇷Goiania, Goiás, Brazil
Multiprofile Hospital for Active Treatment Uni Hospital
🇧🇬Panagyurishte, Bulgaria
Hospital Metropolitano (Sede Lindora-Santa Ana)
🇨🇷San Jose, Costa Rica
Instituto Regional de Enfermedades Neoplásicas del Sur
🇵🇪Arequipa, Peru
Oncocenter Peru S.A.C.
🇵🇪Lima, Peru
National Cancer Centre
🇸🇬Singapore, Singapore
Tan Tock Seng Hospital
🇸🇬Singapore, Singapore
Medical Oncology Centre of Rosebank
🇿🇦Johannesburg, South Africa
Complejo Hospitalario de Jaen-Hospital Universitario Medico Quirurgico
🇪🇸Jaen, Spain
Hospital Universitario Virgen de Arrixaca
🇪🇸Murcia, Spain
Hospital Clinico Universitario de Salamanca
🇪🇸Salamanca, Spain
Ankara City Hospital
🇹🇷Ankara, Turkey
Ba?c?lar Medipol Mega Üniversite Hastanesi
🇹🇷Istanbul, Turkey
Hacettepe Uni Medical Faculty Hospital
🇹🇷Sihhiye/Ankara, Turkey
Fundación CENIT para la Investigación en Neurociencias
🇦🇷Buenos Aires, Argentina
University Clinical Center of the Republic of Srpska
🇧🇦Banja Luka, Bosnia and Herzegovina
Crio - Centro Regional Integrado de Oncologia
🇧🇷Fortaleza, Ceará, Brazil
Clinica de Pesquisa e Centro de Estudos em Oncologia Ginecologica e Mamaria Ltda
🇧🇷Sao Paulo, São Paulo, Brazil
Complex Oncology Center - Plovdiv First Internal Chemotherapy Department
🇧🇬Plovdiv, Bulgaria
MHAT Nadezhda
🇧🇬Sofia, Bulgaria
Royal Victoria Regional Health Centre
🇨🇦Barrie, Ontario, Canada
Lakeridge Health Oshawa
🇨🇦Oshawa, Ontario, Canada
North York General Hospital
🇨🇦Toronto, Ontario, Canada
Jewish General Hospital
🇨🇦Montreal, Quebec, Canada
Hopital du Saint Sacrement
🇨🇦Quebec City, Quebec, Canada
Clinica Vespucio
🇨🇱Santiago, Chile
Centro de Estudios Clínicos SAGA
🇨🇱Santiago, Chile
Clinica CIMCA
🇨🇷San José, Costa Rica
ICIMED Instituto de Investigación en Ciencias Médicas
🇨🇷San José, Costa Rica
Clinical Hospital Centre Zagreb
🇭🇷Zagreb, Croatia
Saifee Hospital
🇮🇳Mumbai, Maharashtra, India
International Cancer Institute (ICI)
🇰🇪Eldoret, Kenya
Aga Khan University Hospital
🇰🇪Nairobi, Kenya
Korea University Anam Hospital
🇰🇷Seoul, Korea, Republic of
Samsung Medical Center
🇰🇷Seoul, Korea, Republic of
Wilgers Oncology Centre
🇿🇦Pretoria, South Africa
Gulhane Training and Research Hospital
🇹🇷Ankara, Turkey
Trakya University Medical Faculty Research And Practice Hospital Medical Oncology Department
🇹🇷Edirne, Turkey
TATA Medical Centre
🇮🇳Kolkata, WEST Bengal, India
Hospital Nossa Senhora da Conceicao
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Health Pharma Professional Research
🇲🇽Cdmx, Mexico CITY, Mexico
Iem-Fucam
🇲🇽D.f., Mexico CITY, Mexico
Oncologico Potosino
🇲🇽San Luis Potosí, SAN LUIS Potosi, Mexico
Aga Khan University Hospital
🇰🇪Nairobi, Kenya
Iem-Fucam
🇲🇽D.f., Mexico CITY, Mexico
Korea University Anam Hospital
🇰🇷Seoul, Korea, Republic of
Samsung Medical Center
🇰🇷Seoul, Korea, Republic of
TATA Medical Centre
🇮🇳Kolkata, WEST Bengal, India
International Cancer Institute (ICI)
🇰🇪Eldoret, Kenya
MHAT Nadezhda
🇧🇬Sofia, Bulgaria
Royal Victoria Regional Health Centre
🇨🇦Barrie, Ontario, Canada
Lakeridge Health Oshawa
🇨🇦Oshawa, Ontario, Canada
North York General Hospital
🇨🇦Toronto, Ontario, Canada
Jewish General Hospital
🇨🇦Montreal, Quebec, Canada
Hopital du Saint Sacrement
🇨🇦Quebec City, Quebec, Canada
Clinica Vespucio
🇨🇱Santiago, Chile
Centro de Estudios Clínicos SAGA
🇨🇱Santiago, Chile
Hospital Metropolitano (Sede Lindora-Santa Ana)
🇨🇷San Jose, Costa Rica
Clinica CIMCA
🇨🇷San José, Costa Rica
ICIMED Instituto de Investigación en Ciencias Médicas
🇨🇷San José, Costa Rica
Clinical Hospital Centre Zagreb
🇭🇷Zagreb, Croatia
Saifee Hospital
🇮🇳Mumbai, Maharashtra, India
Health Pharma Professional Research
🇲🇽Cdmx, Mexico CITY, Mexico
Oncologico Potosino
🇲🇽San Luis Potosí, SAN LUIS Potosi, Mexico
Instituto Regional de Enfermedades Neoplásicas del Sur
🇵🇪Arequipa, Peru
Oncocenter Peru S.A.C.
🇵🇪Lima, Peru
National Cancer Centre
🇸🇬Singapore, Singapore
Tan Tock Seng Hospital
🇸🇬Singapore, Singapore
Medical Oncology Centre of Rosebank
🇿🇦Johannesburg, South Africa
Wilgers Oncology Centre
🇿🇦Pretoria, South Africa
Complejo Hospitalario de Jaen-Hospital Universitario Medico Quirurgico
🇪🇸Jaen, Spain
Hospital Universitario Virgen de Arrixaca
🇪🇸Murcia, Spain
Hospital Clinico Universitario de Salamanca
🇪🇸Salamanca, Spain
Gulhane Training and Research Hospital
🇹🇷Ankara, Turkey
Ankara City Hospital
🇹🇷Ankara, Turkey
Trakya University Medical Faculty Research And Practice Hospital Medical Oncology Department
🇹🇷Edirne, Turkey
Ba?c?lar Medipol Mega Üniversite Hastanesi
🇹🇷Istanbul, Turkey
Hacettepe Uni Medical Faculty Hospital
🇹🇷Sihhiye/Ankara, Turkey
Clinica de Pesquisa e Centro de Estudos em Oncologia Ginecologica e Mamaria Ltda
🇧🇷Sao Paulo, São Paulo, Brazil
Multiprofile Hospital for Active Treatment Uni Hospital
🇧🇬Panagyurishte, Bulgaria
Complex Oncology Center - Plovdiv First Internal Chemotherapy Department
🇧🇬Plovdiv, Bulgaria
Fundación CENIT para la Investigación en Neurociencias
🇦🇷Buenos Aires, Argentina
Centro Oncologico Korben
🇦🇷Ciudad Autonoma Buenos Aires, Argentina
University Clinical Center of the Republic of Srpska
🇧🇦Banja Luka, Bosnia and Herzegovina
Cantonal Hospital Zenica
🇧🇦Zenica, Bosnia and Herzegovina
Crio - Centro Regional Integrado de Oncologia
🇧🇷Fortaleza, Ceará, Brazil
Hospital Araujo Jorge
🇧🇷Goiania, Goiás, Brazil
Hospital Nossa Senhora da Conceicao
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil