Pre-emptive Analgesia Using Nebulized Ketamine Versus Nebulized Dexmedetomidine in Endoscopic Nasal Surgeries

Not Applicable

Recruiting

• Conditions: Nose Diseases
• Interventions: Drug: Dexmedetomidine; Drug: Ketamine; Drug: 0.9%sodium chloride

• Registration Number: NCT07056582
• Lead Sponsor: Sohag University

Brief Summary

this study aims to compare the efficacy of pre-emptive nebulized ketamine versus nebulized dexmedetomidine for post operative pain relief in endoscopic nasal surgery

Detailed Description

Not available

Study Timeline

• Study Start: 2025-04-14
• Status Verified: 2025-06
• Study First Submitted: 2025-06-29
• Study First Submitted QC: 2025-07-08
• Last Update Submitted: 2025-07-08
• Study First Posted: 2025-07-09
• Last Update Posted: 2025-07-09
• Primary Completion: 2025-10-20
• Study Completion: 2025-10-20

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 105

Inclusion Criteria

• patients between the ages of 20 and 60,
• both sexes,
• American Society of Anesthesiologists physical status I to II
• BMI ≥18≤30 kg/m²

Exclusion Criteria

• Patient refusal.
• patients with advanced respiratory, renal, hepatic, neurological, or psychiatric disease, pregnant or nursing women.
• patients with a history of allergies to any study drugs.
• patients who had used central nervous system depressants or analgesics within the previous 24 hours.
• patients with hypertension, hypotension, or bradycardia.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
group D : will receive dexmedetomidine	Dexmedetomidine	Patients will receive nebulized dexmedetomidine 50 μg (0.5 ml +normal saline 0.9% up to 3 ml) 15 minutes prior to the onset of surgery.
group K : will receive ketamine	Ketamine	patients will receive nebulized ketamine 50 mg (1 ml + normal saline 0.9%up to 3 ml) 15 minutes prior to the onset of surgery.
group C: will receive .9% saline	0.9%sodium chloride	Patients will receive nebulized normal saline 0.9% (3 ml) 15 minutes prior to the onset of surgery.

Primary Outcome Measures

Name	Time	Method
This study aims to assess the efficacy of nebulized dexmedetomidine vs nebulized ketamine to achieve good postoperative pain management in patients undergoing endoscopic nasal surgeries.	24 hours after operation	post operative pain management by VAS

Trial Locations

Locations (1)

Sohag university hospital; 🇪🇬 Sohag, Egypt