Perspective Memory and Executive Functions in HIV+ Patients

Recruiting

• Conditions: HIV Infections
• Interventions: Other: Neuropsychological testing

• Registration Number: NCT05752578
• Lead Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Brief Summary

The primary goal of this observational study is to evaluate prospective memory in HIV+ patients compared to healthy subjects. The secondary goal is to examine the relationship between prospective memory and Hot Cognition (mechanical cognitive abilities) and Cold Cognition (cognitive abilities supported by emotion and social perception). The main questions it aims to answer are:

* Do HIV+ patients have more impaired prospective memory than healthy subjects?

* Is there a greater influence of Hot Cognition on prospective memory than Cold Cognition? Participants will undergo a battery of neuropsychological tests: Memory for Intentions Screening Test (MIST), Montreal Cognitive Assessment (MOCA), Interpersonal Reactivity Index and Modified Five Point Test.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-10-10
• Status Verified: 2023-01
• Study First Submitted: 2023-01-30
• Study First Submitted QC: 2023-03-01
• Last Update Submitted: 2023-03-01
• Study First Posted: 2023-03-02
• Last Update Posted: 2023-03-02
• Primary Completion: 2023-12-31
• Study Completion: 2023-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Healthy control subjects	Neuropsychological testing	Both male and female subjects, over the age of 18 years, no neurological or psychiatric conditions that would alter test performance, native speakers of Italian
Subjects with HIV infection	Neuropsychological testing	Both male and female subjects, over 18 years of age, on antiretroviral therapy, native speakers of Italian

Primary Outcome Measures

Name	Time	Method
Prospective memory in HIV+ patients and healthy subjects	1 year	Prospective memory will be assessed through the following test: Memory for Intentions Screening Test (MIST).

Secondary Outcome Measures

Name	Time	Method
Influence of global cognitive performance on prospective memory	1 year	Montreal Cognitive Assessment (MOCA) investigating global cognitive performance.
Influence of hot cognition on perspective memory	1 year	Interpersonal Reactivity Index (IRI) with the purpose of assessing cognitive and affective empathy (Hot cognition).
Influence of cold cognition on perspective memory	1 year	Modified Five Point Test aimed at assessing figurative fluency (Cold cognition).

Trial Locations

Locations (1)

Fondazione Policlinico Universitario Agostino Gemelli IRCCS; 🇮🇹 Roma, Italy