A Study of Decreased Mental Function Associated With HIV
- Conditions
- HIV InfectionsCognitive Disorders
- Registration Number
- NCT00027040
- Brief Summary
The purpose of this study is to compare pictures of the brain of HIV-infected people with memory problems before and after treatment with selegiline. Selegiline is the study drug received through A5090.
HIV patients generally develop memory problems late in the disease. This will be examined using noninvasive proton magnetic resonance spectroscopy (1H-MRS). The effect of the drug selegiline on memory problems also will be examined.
- Detailed Description
HIV-associated cognitive impairment generally develops during the later stages of the disease. This study proposes to non-invasively examine the pattern and extent of cerebral injury associated with HIV infection and its response to selegiline by using 1H-MRS. The following hypotheses will be tested: selegiline, a compound with antioxidant and anti-apoptotic properties, will reverse the metabolic abnormalities measured by 1H-MRS, and these changes will parallel the degree of improvement in cognitive and functional performance.
This is a substudy of ACTG A5090. The pattern and extent of cerebral injury associated with HIV infection and its response to selegiline are examined using a 1H-MRS. 1H-MRS evaluations are performed at screening and Week 24 (or at the time of premature discontinuation) of Step 1 of A5090. The screening MRS exams may only be performed once all A5090 screening evaluations (including the lumbar puncture) have been completed and it has been determined that the patient is eligible for A5090 study entry.
The screening MRS must be performed prior to A5090 study drug administration. The Week-24 MRS must be performed while the patient is still on blinded study drug.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 90
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (12)
UCLA CARE Ctr
🇺🇸Los Angeles, California, United States
Univ of California, San Diego
🇺🇸San Diego, California, United States
Stanford University
🇺🇸Stanford, California, United States
Johns Hopkins Hosp
🇺🇸Baltimore, Maryland, United States
Mount Sinai Med Ctr
🇺🇸New York, New York, United States
Columbia Presbyterian Med Ctr
🇺🇸New York, New York, United States
Univ of Rochester Medical Center
🇺🇸Rochester, New York, United States
Univ of Pennsylvania
🇺🇸Philadelphia, Pennsylvania, United States
Rhode Island Hosp
🇺🇸Providence, Rhode Island, United States
Stanley Street Treatment and Resource
🇺🇸Providence, Rhode Island, United States
Univ of Washington
🇺🇸Seattle, Washington, United States
The Miriam Hosp
🇺🇸Providence, Rhode Island, United States