Dexmedetomidine in Sonographic Guided Erector Spinae Plane Block

Phase 2

Recruiting

• Conditions: Pain Management
• Interventions: Drug: Dexmedetomidine

• Registration Number: NCT06899841
• Lead Sponsor: Assiut University

Brief Summary

to investigate the postoperative analgesic effect of dexmedetomidine addition with different doses as an adjuvant to bupivacaine to Erector spinae plane block after renal surgeries.

Detailed Description

Not available

Study Timeline

• Study Start: 2024-10-01
• Status Verified: 2025-03
• Study First Submitted: 2025-03-16
• Study First Submitted QC: 2025-03-21
• Last Update Submitted: 2025-03-21
• Study First Posted: 2025-03-28
• Last Update Posted: 2025-03-28
• Primary Completion: 2025-10-01
• Study Completion: 2026-04-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• Age between 18 and 70 years.
• Both sexes, males and females.
• Patients with the American Society of Anesthesiologists (ASA) physical status I/II.
• Body mass index (BMI) of 18-35 kg/m2
• Patients scheduled for elective Renal or Percutaneous Nephrolithotomy.

Exclusion Criteria

• Patients under 18 years.
• Patient refusal of nerve block.
• Infection at the site of injection.
• Coagulopathy.
• Allergy to used medications.
• Psychiatric disorder or chronic pain syndromes.
• Chronic opioid use or substance abuse.
• Quadriplegic patients.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
low dose dex	Dexmedetomidine	0.5 mic/kg of dexmedetomidine administered
high dose dex	Dexmedetomidine	1 mic/kg of dexmedetomidine administered
intermediate dose dex	Dexmedetomidine	0.75 mic/kg of dexmedetomidine administered

Primary Outcome Measures

Name	Time	Method
postoperative analgesic duration	24 hours	postoperative analgesic duration with each dose

Secondary Outcome Measures

Name	Time	Method
Pain score	24 hours	severity of pain using visual analogue pain score
side effects	24 hours	as hemodynamic effect as (hypotension, bradycardia), nausea and vomiting.
dynamic pain score	24 hours	Dynamic visual analogue pain score (pain with cough, deep breath, and movement)

Trial Locations

Locations (1)

Assiut University Hospitals; 🇪🇬 Assiut, Assiut Governorate, Egypt