The Effect of Sprouting of Wheat on Postprandial Glycemic and Satiety Responses of Wheat Bread Products

Not Applicable

Completed

• Conditions: Blood Sugar
• Interventions: Other: Bread

• Registration Number: NCT05526937
• Lead Sponsor: University of Guelph

Brief Summary

The objective of this study is to investigate the effect of inclusion of 50% sprouted wheat wholemeal in a bread recipe on the postprandial glycemic and satiety responses, as well as on appetite-related sensations and acceptability of the developed products relative to a product made with a similar unsprouted wheat recipe.

Detailed Description

This study is a randomized crossover trial involving three different bread products. At each study visit, capillary blood glucose will be measured at fasting, and then 15, 30, 45, 60, 90, and 120 minutes following the start of ingestion of the study food. Visual analogue scales will be used to assess appetite and fullness sensations at fasting, and then 30, 60, 90 and 120 minutes.

Study Timeline

• Study First Submitted: 2022-08-31
• Study First Submitted QC: 2022-08-31
• Study First Posted: 2022-09-02
• Study Start: 2022-10-18
• Primary Completion: 2023-03-15
• Study Completion: 2023-05-15
• Status Verified: 2023-12
• Last Update Submitted: 2023-12-04
• Last Update Posted: 2023-12-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

• Healthy adults
• Age 18-40 years
• Normal non-fasting plasma glucose (<7.9 mmol/L but not below 3.3 mmol/L)
• BMI ranging from 18.5 to 27.9 kg/m2
• Regular consumer of wheat-based bread products (>1x per week).

Exclusion Criteria

• Smoking or regular use of recreational drugs (marijuana, ecstasy, LSD, magic mushrooms etc.)
• Heavy alcohol use (defined as typically >14 drinks per week or >4 drinks on one occasion)
• Restrained eater (>16) as defined by the questionnaire at screening (Appendix E: Three Factor Eating Questionnaire, Stunkard et al.,1985)
• Unusual sleep patterns (Shift-worker, or sleeps 4 hours or less regularly) or irregular breakfast consumption.
• Recent (i.e. >4 kg in previous 3 months) or intended weight loss or gain
• Food allergies or any life-threatening allergy (food or otherwise)
• Gluten intolerance or sensitivity
• Medications known to affect glucose tolerance (excluding oral contraceptives)
• Presence of disease or drug(s) which influence digestion and absorption of nutrients; including steroids, protease inhibitors or antipsychotics.
• Inability to adhere to Study Protocols

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Sprouted wholemeal bread	Bread	-
Unsprouted wholemeal bread	Bread	-
White bread	Bread	-

Primary Outcome Measures

Name	Time	Method
Postprandial glycemic response	2 hours	Capillary blood glucose

Secondary Outcome Measures

Name	Time	Method
Postprandial satiety response	2 hours	Hunger, Fullness, Desire to Eat and Prospective Food Consumption questions using Visual Analogue Scales (100 mm lines). Answers are measured and scored from 0 (not at all) to 100 (extreme).

Trial Locations

Locations (1)

Human Nutraceutical Research Unit; 🇨🇦 Guelph, Ontario, Canada