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Clinical Trials/NCT05668546
NCT05668546
Completed
Not Applicable

Is Isokinetic Knee Muscle Strength an Indicator of Total Knee Arthroplasty

Bahçeşehir University1 site in 1 country29 target enrollmentApril 1, 2021

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Knee Osteoarthritis
Sponsor
Bahçeşehir University
Enrollment
29
Locations
1
Primary Endpoint
Osteoartritis gradings assessed by Kellgren-Lawrence grading system
Status
Completed
Last Updated
3 years ago

Overview

Brief Summary

In this study, investigators analyzed whether the isokinetic knee muscle strength of patients undergoing unilateral total knee arthroplasty (TKA) is a predictor for surgery.

Patients and Methods: In total, 29 unilateral TKA candidates (58 knees; mean age = 66.69 ± 7.42 years; mean symptom duration = 10 ± 5.40 years) were enrolled. The knees of patients with bilateral advanced knee osteoarthritis (stage 3 or 4), according to the Kellgren-Lawrence (K-L scale), that were scheduled for unilateral TKA were divided into surgical and non-surgical groups. An isokinetic testing system was used to assess knee flexor and extensor muscle strength (peak torque) at angular velocities of 60°/s and 180°/s (five cycles per velocity). The radiological (X-ray-based K-L scale and magnetic resonance imaging (MRI)-based quadriceps angle) and clinical findings (isokinetic test and visual analog scale pain scores) in both groups were compared. The isokinetic test results correlated with the radiological findings of the surgery group.

Registry
clinicaltrials.gov
Start Date
April 1, 2021
End Date
February 1, 2022
Last Updated
3 years ago
Study Type
Interventional
Study Design
Crossover
Sex
All

Investigators

Sponsor
Bahçeşehir University
Responsible Party
Principal Investigator
Principal Investigator

Ilknur Saral

Ass. Prof.

Bahçeşehir University

Eligibility Criteria

Inclusion Criteria

  • Diagnosis of advanced (Kellgren-Lawrence stage 3 or 4) bilateral knee osteoarthritis (OA).
  • Unilateral total knee replacement surgery recommended by orthopedics according to pain status

Exclusion Criteria

  • Neurological diseases that could affect knee muscle strength
  • Rheumatological diseases
  • Diagnosis of osteoarthritis below 3 according to Kellgren-Lawrence classification

Outcomes

Primary Outcomes

Osteoartritis gradings assessed by Kellgren-Lawrence grading system

Time Frame: cross sectional study, baseline

Kellgren-Lawrence grading system was used. Each radiograph was assigned a grade from 0 to 4, which correlated to increasing severity of OA, with Grade 0 signifying no presence of OA and Grade 4 signifying severe OA

Quadriceps angle

Time Frame: cross sectional study, baseline

Q angle of knees were recorded. It is defined as the angle formed between the quadriceps muscles and the patella tendon.The Q angle measured in standing. Normal Q angle score for females is between 13-18° and in males is between 12-15°, with values greater than and lesser these are considered abnormal

Knee flexion and extension muscle strengths assessed by isokinetic dynamometer

Time Frame: cross-sectional study, baseline

In the isokinetic evaluation, both 60 PT_E (Peak Torque _Extension) and 60 PT_F (Peak Torque_Flexion) were evaluated.The tests were repeated five times at each velocity, and the highest PTs were selected for statistical analysis. The participants performed repeated trials before sets, while a 20-second rest was provided between sets.

Pain assessed by Visual analog scale

Time Frame: cross sectional study, baseline

The visual analog scale (VAS) pain score of each individual was also recordedThe Visual Analogue Scale (VAS) measures pain intensity. The VAS consists of a 10cm line, with two end points representing 0 ('no pain') and 10 ('pain as bad as it could possibly be'). Investigators asked the patient to rate their current level of pain by placing a mark on the line.

Study Sites (1)

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