Intra-Articular Dexmedetomidine: A Treatment for Chronic Knee Pain

Not Applicable

Recruiting

• Conditions: Chronic Knee Pain
• Interventions: Drug: Triamcinolone Acetonide; Drug: Dexmedetomidine; Drug: Bupivacaine Hydrochloride

• Registration Number: NCT06641206
• Lead Sponsor: Tanta University

Brief Summary

Chronic knee osteoarthritis (KOA) is a painful condition with limited treatment options. Non-pharmacological approaches often fall short, leading to decreased quality of life. Ozone therapy, a simple and affordable treatment, has shown promise for pain relief. Dexmedetomidine (DEX), a sedative and analgesic, has been used successfully as an adjuvant to anesthesia and local anesthetics. Given its potential for pain management, exploring DEX as a treatment for KOA could offer a new and promising approach.

Detailed Description

Not available

Study Timeline

• Study Start: 2024-09-17
• Status Verified: 2024-10
• Study First Submitted: 2024-10-11
• Study First Submitted QC: 2024-10-11
• Last Update Submitted: 2024-10-11
• Study First Posted: 2024-10-14
• Last Update Posted: 2024-10-14
• Primary Completion: 2025-01
• Study Completion: 2025-03

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

• Patients were not assigned for surgical intervention;
• Patients were free of exclusion criteria

Exclusion Criteria

• Patients were assigned for surgical intervention;
• Patients who had uncontrolled hypertension and/or diabetes mellitus;
• Patients who had uncompensated cardiac, renal, or hepatic diseases;
• Patients with coagulopathy, spinal deformity, allergy, or contraindication for the used drugs;
• Patients who refused to sign the informed consent were excluded from the study.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Group 1	Triamcinolone Acetonide	A group of Patients from Tanta University suffering from Chronic painful knee osteoarthritis who didn't receive medical treatment and progressed to have chronic pain with decreased physical function and poorer quality of life.
Group 1	Bupivacaine Hydrochloride	A group of Patients from Tanta University suffering from Chronic painful knee osteoarthritis who didn't receive medical treatment and progressed to have chronic pain with decreased physical function and poorer quality of life.
Group 2	Dexmedetomidine	A group of Patients from Tanta University suffering from Chronic painful knee osteoarthritis who didn't receive medical treatment and progressed to have chronic pain with decreased physical function and poorer quality of life.

Primary Outcome Measures

Name	Time	Method
Proportion of patients reporting at least a 50% reduction in pain (measured by Numerical Rating Scale) post-intra-articular Injection.	7 months	Value of intra-articular Injection in Pain Reduction of chronic knee pain manifested by recurrence of pain.

Trial Locations

Locations (1)

Tanta University; 🇪🇬 Tanta, El Gharbyia, Egypt