Brain Mechanisms Underlying the Effect of the Motilin Receptor Agonist Erythromycin on Hunger in Normal Weight Subjects
- Registration Number
- NCT02212821
- Lead Sponsor
- Universitaire Ziekenhuizen KU Leuven
- Brief Summary
The purpose of this study is to investigate the role of erythromycin, a prokinetic agent, on hunger, and the brain mechanism lying behind it.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 14
Inclusion Criteria
- Female only.
- Age > 18 and < 60.
- Body Mass Index (BMI) of 19-25 kg/m2 (no weight change of more than 5 kg in the past three months).
- Not known to have any chronic medical illness or illnesses affecting the gastrointestinal, cardiovascular, or nervous systems, chronic pain or psychiatric disorder.
- If female not known to be pregnant.
- Not known to have any past upper gastrointestinal surgery.
Exclusion Criteria
- Alcohol consumption > 7 drinks / week
- Major depression and chronic health conditions except controlled hypertension
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Placebo Placebo intravenous infusion Erythromycin Erythromycin intravenous infusion
- Primary Outcome Measures
Name Time Method Functional brain images 40 min after intervention The functional brain images will be taken via functional magnetic resonance imaging (fMRI), and be analysed via a software called SPM.
- Secondary Outcome Measures
Name Time Method hunger scores every 10 minutes since the scan starts The hunger scores will be taken every 10 minutes since the scan starts via a 10 cm visual analogue scale.
gut hormones every 10 min since the scan starts Peripheral blood samples will be taken every 10 min since the scan starts until the endpoint of the study to measure gut hormones (motilin, ghrelin, CCK, PYY, GLP-1) by radioimmuno-assay.