NCT02212821已完成4 期
Brain Mechanisms Underlying the Effect of the Motilin Receptor Agonist Erythromycin on Hunger in Normal Weight Subjects
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 14
- 主要终点
- Functional brain images
研究概览
简要总结
The purpose of this study is to investigate the role of erythromycin, a prokinetic agent, on hunger, and the brain mechanism lying behind it.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Female only.
- •Age > 18 and <
- •Body Mass Index (BMI) of 19-25 kg/m2 (no weight change of more than 5 kg in the past three months).
- •Not known to have any chronic medical illness or illnesses affecting the gastrointestinal, cardiovascular, or nervous systems, chronic pain or psychiatric disorder.
- •If female not known to be pregnant.
- •Not known to have any past upper gastrointestinal surgery.
排除标准
- •Alcohol consumption > 7 drinks / week
- •Major depression and chronic health conditions except controlled hypertension
研究组 & 干预措施
Placebo
Placebo Comparator
intravenous infusion
干预措施: Placebo (Drug)
Erythromycin
Experimental
intravenous infusion
干预措施: Erythromycin (Drug)
结局指标
主要结局
Functional brain images
时间窗: 40 min after intervention
The functional brain images will be taken via functional magnetic resonance imaging (fMRI), and be analysed via a software called SPM.
次要结局
- hunger scores(every 10 minutes since the scan starts)
- gut hormones(every 10 min since the scan starts)
研究者
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