The Effect of Motilin on the Frequency and Amount of Food Intake
- Registration Number
- NCT03024879
- Lead Sponsor
- Universitaire Ziekenhuizen KU Leuven
- Brief Summary
In this study, the investigators aimed at evaluating the role of motilin in the regulation of food intake. Motilin, a gastrointestinal hormone, is a hunger signal in healthy volunteers and is significantly increased in obese patients. Its role in food intake regulation might contribute to the pathogenesis of obesity.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ENROLLING_BY_INVITATION
- Sex
- All
- Target Recruitment
- 15
Inclusion Criteria
- BMI < 30 kg/m² for lean volunteers
- BMI > 30 kg/m² for obese volunteers
- Subject is capable and willing to give informed consent
- Female volunteers of child bearing potential must use oral, injected or implanted hormonal methods of contraception
Exclusion Criteria
- Female volunteer is pregnant or breastfeeding
- GI diseases, major abdominal surgery
- Major psychiatric illnesses
- Volunteers that use drugs affecting the GI tract or the central nervous system
- Volunteers suffering from endocrine diseases such as diabetes, Cushing's disease, Addison's disease, hypothalamic tumor
- Volunteers that have undergone surgical procedure for weight loss
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Placebo Saline a saline solution of 100 ml will be administered intravenously over a period of 20 min Erythromycin Erythromycin 40 mg of erythromycin will be administered intravenously over a period of 20 min in a saline solution of 100 ml
- Primary Outcome Measures
Name Time Method Change in food intake, assessed by caloric intake, after intravenous administration of erythromycin compared to placebo Caloric intake will be assessed 1 hour after the start of infusion and the start of ad libitum food intake
- Secondary Outcome Measures
Name Time Method Frequency of food intake correlated with motilin plasma levels Assessment will be done over a period of 5 hours