NCT04577170已完成不适用
Association of the Pulsatility Index and Vasomotor Reactivity With White Matter Lesions in Brain MRI of Fabry Disease Patients
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 45
- 试验地点
- 1
- 主要终点
- Prevalence of elevated pulsatility index of FD patients
研究概览
简要总结
We hypothesize that Fabry disease - FD is associated with elevated vascular resistance induced by cerebral small-vessel disease, indicating increased distal resistance to blood flow. The findings of this study may be used as a precursor for neuroimaging manifestations related to stroke in FD patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 16 Years 至 70 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Fabry disease diagnosis, genetically confirmed Age> 16 years
排除标准
- •Insufficient temporal bone window MRI contra-indication Inability to cooperate for breath-holding test Detection of atrial fibrillation Refuse to sing informed consent
结局指标
主要结局
Prevalence of elevated pulsatility index of FD patients
时间窗: 2 years
to assess the prevalence of elevated pulsatility index in FD patients at a single time point.
Prevalence of elevated vasomotor reactivity in FD patients.
时间窗: 2 years
to assess the prevalence of elevated vasomotor reactivity in FD patients at a single time point.
次要结局
- Τo compare vasomotor reactivity measured in FD patients against corresponding prospectively collected data from healthy individuals, stratified by age and sex.(2 years)
- Association of vasomotor reactivity with leukoencephalopathy in FD patients.(2 years)
- Association of pulsalitily index with leukoencephalopathy in FD patients.(2 years)
- Τo compare the pulsatility index measured in FD patients against corresponding prospectively collected data from healthy individuals, stratified by age and sex.(2 years)
研究者
Georgios Tsivgoulis
Professor
National and Kapodistrian University of Athens
研究点 (1)
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