NCT00889993已完成不适用
Effect of Four Doses of Mixed Fiber on Satiety, Food Intake, Glucose, Insulin, and Gut Hormone Release
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Satiety and Food Intake
研究概览
简要总结
People who eat more dietary fiber have a lower body weight than people who eat less fiber. Potential mechanisms include greater feelings of satiety, reductions in food intake, changes in blood glucose, insulin, or gut hormones.
The investigators hypothesize that increasing doses of mixed fiber will influence satiety response, food intake, glucose, insulin, ghrelin, GLP-1, and PYY 3-36, in a dose-dependent manner, when given to subjects in muffins for breakfast.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •English speaking
- •healthy men and women
- •18 and 65 years of age
- •non-smoking
- •not taking medications
- •non-dieting (weight stable over last 3 months)
- •BMI between 18 and 27
- •able to give blood through an IV
排除标准
- •irregular or erratic breakfast eating patterns
- •food allergies to ingredients commonly found in muffins or pizza
- •distaste for muffins or pizza
- •BMI less than 18 or greater than 27
- •weight change > 5 kg in last 3 months (intentional or unintentional)
- •cardiovascular disease
- •diabetes mellitus (fasting blood sugar > 126 mg/dl)
- •cancer in prior 5 years (except basal cell carcinoma of skin)
- •renal or hepatic disease
- •Crohns disease
- •ulcerative colitis
- •any other gastrointestinal conditions that may affect digestion or absorption
- •recent bacterial infection (< 3 months)
- •chronic medication use
- •history of drug or alcohol abuse in prior 6 months
- •concurrent or recent intervention study participation
- •vegetarians
- •people who ate more than approximately 15 g of fiber per day
- •pregnant or lactating women
- •women with irregular menstrual cycles
结局指标
主要结局
Satiety and Food Intake
时间窗: November 2007 thru May 2008
次要结局
- Glucose, Insulin, Gut Hormone Response(November 2007 thru October 2008)
研究者
研究点 (2)
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