Long Term Tapering or Standard Steroids for Nephrotic Syndrome
Phase 4
- Conditions
- Nephrotic Syndrome
- Registration Number
- NCT00308321
- Lead Sponsor
- Institute of Child Health
- Brief Summary
Parallel group double blind randomised in patients with first episode corticosteroid sensitive nephrotic syndrome comparing time to relapse and adverse effects associated with a longer tapering steroid regimen with standard regime
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
- newly presenting nephrotic syndrome, urine albumin/protein creatinine ratio >200mg/mmol on early morning urine sample, hypoalbuminemia (<25g/L)
Exclusion Criteria
- prior treatment with steroids or cytotoxic agents underlying systemic disorder or exposure to agents known to be associated with newly presenting steroid sensitive nephrotic syndrome
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Time to first relapse 5 months Assessment of steroid induced morbidity 5 months
- Secondary Outcome Measures
Name Time Method frequent relapsing and steroid dependant disease 5 months Time to relapse 5 months serious adverse events 5 months use of other immunosuppressive agents 5 months Achenbach child behaviour checklist 5 months
Trial Locations
- Locations (1)
Institute of Child Health
🇬🇧London, United Kingdom