The effects of additional protein intake on muscle strength and physical performance in physically active elderly
- Conditions
- sarcopenia, frailty, loss of muscle mass, strength and functionality<br />sarcopenie, fragiliteit, verlies aan spiermassa, kracht en functionaliteit
- Registration Number
- NL-OMON23080
- Lead Sponsor
- Radboudumc Nijmegen, Netherlands
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 120
Inclusion Criteria
65 years or older
- Registered for the Nijmegen Four Days Marches 2017
Exclusion Criteria
- Type I or type II diabetes
- Allergic or sensitive for milk proteins, or lactose intolerant.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Change in maximal voluntary contraction (3 repeated measures (RM) leg extension strength test) and physical performance (SPPB) will be our primary outcome measures.
- Secondary Outcome Measures
Name Time Method Secondary study parameters are changes in: <br /><br>oMuscle contractile function*<br /><br>oHandgrip strength and microFET (dynamometer)<br /><br>oTimed up-and-go (TUG)<br /><br>oAnthropometrics<br /><br>oBody composition (DEXA)<br /><br>*Performed in a subgroup of 60 subjects (30 intervention, 30 placebo)<br /><br>Other parameters are: <br /><br>oPhysical fitness (Åstrand-Rhyming test)<br /><br>oPhysical activity (SQUASH) and exercise training (diary)<br /><br>oDaily dietary and protein intake (two 24h-recalls + FFQ)<br /><br>oCompliance (protein supplementation)<br /><br>oBlood analyses<br /><br>oUrine analyses<br /><br>oMedical history questionnaire<br /><br>oQuestionnaire screening sarcopenia (SARC-F)<br /><br>oQuestionnaire quality of life (EQ5D)<br /><br>oQuestionnaires muscle complaints (Short-Form McGill Pain Questionnaire (SF-MPQ) and Short-Form Brief Pain Inventory (BPI-SF))