Glymphatic Function TMS Study

Not Applicable

Not yet recruiting

• Conditions: Mild Cognitive Impairment

• Registration Number: NCT07192913
• Lead Sponsor: University of Arizona

Brief Summary

The purpose of this study is to use transcranial magnetic stimulation (TMS) in older adults to impact the glymphatic system. The glymphatic system is a brain-wide clearance pathway that plays a crucial role in removing dysfunctional proteins in Alzheimer's disease. This project aims to investigate if TMS can help glymphatic function and reduce levels of these proteins in those with mild cognitive impairment.

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-09
• Study First Submitted: 2025-09-12
• Study First Submitted QC: 2025-09-24
• Last Update Submitted: 2025-09-24
• Study First Posted: 2025-09-25
• Last Update Posted: 2025-09-25
• Study Start: 2025-10-01
• Primary Completion: 2026-07
• Study Completion: 2026-07-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Individuals with mild cognitive impairment (MCI Group)

Inclusion Criteria:

• Age 18-85 years
• MCI subjective criteria: self- or informant-reported cognitive complaint
• Objective cognitive impairment supported by one of the following measures of general cognitive function: (a) classified as MCI via the NACC-UDS 3.0 neuropsychological battery using the typical neuropsychological criteria for MCI diagnosis (1 score on any test at least1.5 SD below the mean); or (b) classified as MCI via the NACC-UDS 3.0 neuropsychological battery using the Jak/Bondi neuropsychological criteria for MCI diagnosis(2 scores at least 1 SD below the mean in one domain, or 3 scores at least 1SD below the mean across domains)
• Right-handed
• English speaking
• Able to attend daily intervention and outcome measurements for ~15 days over a 6 month period.
• Not enrolled in another interventional study within 6 months prior to beginning this study

Exclusion Criteria

• Contraindications to transcranial magnetic stimulation (TMS) or magnetic resonance imaging (MRI)
• Reported sudden or steep decline of cognitive performance
• Telephone Interview for cognitive impairment (TICS) score
• Other neurological disorders (e.g., stroke, head injuries, or multiple sclerosis)
• Psychiatric disorder (except stable late-life depression due to its high prevalence in MCI individuals)
• Current cancer treatment or other comorbid/unstable medical conditions that might independently affect cognitive function

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
NIH Toolbox	Day 1(baseline for block 1), Day 14(post block 1), Day 70 (Baseline block 2), Day 84 (post block 2)	The NIH Toolbox Cognition Battery, recommended for ages 7+, consists of tests of multiple constructs. It yields individual test scores and the following summary scores: Total Cognition Composite, Fluid Composite (includes Dimensional Change Card Sort, Flanker Inhibitory Control and Attention, Picture Sequence Memory (Form A), List Sorting Working Memory, and Pattern Comparison tests), and Crystallized Composite (includes Picture Vocabulary and Oral Reading Recognition tests).