Liposomal Bupivacaine With Standard Bupivacaine Versus Dexmedetomidine With Standard Bupivacaine
- Conditions
- Acute Pain
- Interventions
- Registration Number
- NCT06235606
- Lead Sponsor
- The University of Hong Kong
- Brief Summary
Brachial plexus blocks (BPB) are commonly used to provide regional anaesthesia for patients undergoing distal radial fracture surgery. Distal radial (DR) fracture surgery is a commonly performed orthopaedic surgery and is usually associated with moderate postoperative pain. Poor postoperative pain control can impair rehabilitation, delay recovery and negatively impact outcomes after surgery. Liposomal bupivacaine (EXPAREL) is a multivesicular formulation of bupivacaine that allows rapid absorption and prolonged release of bupivacaine. Liposomal bupivacaine may provide prolonged analgesia for up to 72 hours after single injection and may therefore achieve greater analgesic efficacy compared to non-liposomal long-acting local anaesthetics. The addition of additive drugs such as dexmedetomidine to regional nerve blocks can also extend analgesia and improve postoperative pain. However, the effect of adding liposomal bupivacaine versus adding dexmedetomidine in regional nerve blocks is not known. In this project, the investigators propose to conduct a randomized controlled trial to investigate the effect of adding liposomal bupivacaine versus dexmedetomidine in the supraclavicular BPB for acute postoperative analgesia. The investigators will also assess longer term secondary outcomes including upper limb functional scores, chronic pain, and health related quality of life.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 96
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description To receive supraclavicular BPB using dexmedetomidine with standard bupivacaine Dexmedetomidine 0.5milligram (50micrograms) 19.5ml of 0.5% plain bupivacaine and 0.5ml (50mcg) of dexmedetomidine will be injected. To receive supraclavicular BPB using liposomal bupivacaine with standard bupivacaine Bupivacaine Liposome 13.3 Milligrams/Milliliter [Exparel] 10ml of 0.5% plain bupivacaine and 10ml of 1.33% liposomal bupivacaine will be injected.
- Primary Outcome Measures
Name Time Method Weighted area under curve (AUC) pain score at rest 0-48 hours after surgery Pain severity would be rated at rest after surgery using numerical rating scale (NRS) with 0 to 10 where 0=no pain and 10=the worst possible pain
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
The University of Hong Kong
ðŸ‡ðŸ‡°Hong Kong, Hong Kong