The Effect of Hydration on Postprandial Metabolic Responses

Not Applicable

Not yet recruiting

• Conditions: Glycaemia

• Registration Number: NCT06825962
• Lead Sponsor: Loughborough University

Brief Summary

Certain populations, such as industrial workers and endurance athletes are particularly susceptible to dehydration due to exposure to heat for long periods of time causing evaporative water loss via sweating. The physical and cognitive decrements associated with dehydration have been widely researched, however the effect of dehydration on metabolism is lesser known. As climate change is causing temperatures to rise, and metabolic diseases such as type 2 diabetes are more common, the effect of dehydration on metabolism, specifically glycemic response to meals, needs to be established for future recommendations in clinical, environmental and athletic settings.

Therefore, the aim of this study is to investigate the effect of acute exercise-induced dehydration on subsequent metabolic responses to feeding (i.e. glycaemia and insulinaemia).

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-02
• Study First Submitted: 2025-02-04
• Study First Submitted QC: 2025-02-10
• Last Update Submitted: 2025-02-10
• Study First Posted: 2025-02-13
• Last Update Posted: 2025-02-13
• Study Start: 2025-03
• Primary Completion: 2025-11
• Study Completion: 2025-12

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 16

Inclusion Criteria

• Male or female
• Generally fit and healthy
• Participate in endurance or intermittent exercise at least 3 times a week or minimum of 150 minutes moderate intensity activity per week

Exclusion Criteria

• < 18 or > 45
• Any health condition that may affect study outcomes (e.g., endocrine/liver/renal/cardiovascular disease)
• Any morbidity that affects ability to cycle
• Smoker or vaper

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Plasma glucose	6 hours	Measured using colorimetric assay from venous blood samples

Secondary Outcome Measures

Name	Time	Method
Plasma insulin	6 hours	Measured using ELISA from venous blood samples
Plasma osmolality	6 hours	Measured using freezing point depression from venous blood samples
Plasma volume change	6 hours	Determined from haemoglobin and haematocrit measures in blood samples collected before and after drink ingestion
Urine volume	6 hours	Determined from urine samples collected before and after exercise
Body mass	6 hours	Determined from weighing participants before and after exercise
Urine specific gravity/osmolality	6 hours	Determined from urine samples collected before and after exercise
Thirst sensation	6 hours	Measured via 100 mm visual analogue scales 0 mm = not at all thirsty 100 mm = extremely thirsty
Hunger sensation	6 hours	Measured via 100 mm visual analogue scales 0 mm = not at all hungry 100 mm = extremely hungry
Fullness sensation	6 hours	Measured via 100 mm visual analogue scales 0 mm = not at all full 100 mm = extremely full
Core body temperature	6 hours	Measured via ingestible pill
Blood pressure	6 hours	Measured via and automated sphygmomanometer

Trial Locations

Locations (1)

Loughborough University; 🇬🇧 Loughborough, Leicestershire, United Kingdom