Impact of Transcranial Slow Oscillating Stimulation on Memory Consolidation During Slow Wave Sleep of a Daytime Nap in Patients With Mild Cognitive Impairment(MCI)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 16
- 试验地点
- 2
- 主要终点
- Retention of declarative memories after 0.75 Hz stimulation during SWS, vs after sham stimulation during SWS
研究概览
简要总结
The beneficial effect of nocturnal as well as daytime sleep on memory consolidation is well-documented in young, healthy subjects. Slow wave sleep (SWS), in particular, with its slow oscillating activity have shown to enhance declarative, hippocampus-dependent memory representations. This impact of sleep on memory performance can be additionally enhanced by exogeneous induction of transcranial slow oscillating stimulation (tSOS) within the frequency range of SWS in humans (0,7- 0,8 Hz) during sleep, as has been demonstrated in young, healthy subjects. If patients with amnestic mild cognitive impairment (MCI)- usually characterized by initial difficulties in hippocampus dependent memory functions - benefit from transcranial slow oscillatory stimulation (tSOS) during sleep as well has not been studied so far. The primary goal of the study is therefore to investigate the impact of oscillating current stimulation (tSOS) during a daytime nap on declarative memory consolidation in MCI patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 50 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •amnestic and amnestic plus MCI-patients:
- •Concern reflecting a change in cognition reported by patient or informant or clinician (i.e., historical or observed evidence of decline over time)
- •Objective evidence of memory impairment; additional cognitive domains may be affected as well;
- •Preservation of independence in functional abilities
- •no dementia
- •age: 50-90 years
排除标准
- •untreated severe internal or psychiatric diseases
- •other severe neurological diseases eg., previous major stroke, brain tumour
- •contraindications to MRI
结局指标
主要结局
Retention of declarative memories after 0.75 Hz stimulation during SWS, vs after sham stimulation during SWS
时间窗: 4 Weeks
Retention between stimulation conditions (0.75 Hz during SWS, vs sham stimulation during SWS) in the declarative memory task.
次要结局
- Amount of Slow wave Sleep, spindels, eeg-correlates, further memory systems(4 Weeks)
研究者
Agnes Flöel
Prof. Agnes Flöel, MD
Charite University, Berlin, Germany