Effects of Brain Stimulation During Daytime Nap on Memory Consolidation in Younger, Healthy Subjects

Not Applicable

Completed

• Conditions: Healthy Subjects
• Interventions: Device: no stimulation; Device: brain stimulation

• Registration Number: NCT01840865
• Lead Sponsor: Charite University, Berlin, Germany

Brief Summary

The beneficial effect of daytime sleep on memory consolidation has been shown in young, healthy subjects. Especially, periods rich in slow-wave sleep (SWS) have shown a memory enhancing effect on hippocampus-dependent declarative memory. Slow oscillatory activity typically occuring during SWS has been implicated in the consolidation effect. In this study we investigate if the consolidation effect can be amplified by the application of a weak transcranial oscillatory electric current within the frequency range of SWS in humans (0,7-0,8 Hz) during daytime SWS.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2013-04-18
• Study First Submitted QC: 2013-04-23
• Study First Posted: 2013-04-26
• Study Start: 2013-10
• Primary Completion: 2015-01
• Study Completion: 2015-01
• Status Verified: 2016-03
• Last Update Submitted: 2016-03-15
• Last Update Posted: 2016-03-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 22

Inclusion Criteria

• healthy Subjects
• unobtrusive, neuropsychological screening
• age: 18-35 years
• right handed

Exclusion Criteria

• untreated severe internal or psychiatric diseases
• epilepsy
• other severe neurological diseases eg., previous major stroke, brain tumour
• contraindications to MRI

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
SHAM stimulation	no stimulation	SHAM stimulation during periods of Slow Wave Sleep
0,75 Hz stimulation	brain stimulation	slow transcranial oscillating stimulation (\~0,75Hz) during periods of Slow Wave Sleep

Primary Outcome Measures

Name	Time	Method
Retention of declarative memories after 0.75 Hz stimulation during SWS, vs after sham stimulation during SWS	4 weeks	Retention between stimulation conditions (0.75 Hz during SWS, vs sham stimulation during SWS) in the declarative memory task.

Secondary Outcome Measures

Name	Time	Method
4. further memory systems	4 weeks	4. Performance in further memory systems (procedural), compared between 0,75 Hz and SHAM stimulation during SWS.
3. EEG-correlates	4 weeks	3. Neuronal correlates (EEG-power in slow oscillation frequency bands induced by 0,75 Hz vs SHAM stimulation during SWS; EEG-correlates of encoding and retrieval of a declarative memory task).
2. sleep spindles	4 weeks	2. Spindle activity during sleep indicated via several spindle parameters like number, duration, frequency of spindles; compared between 0,75 Hz and SHAM stimulation during SWS.
Amount of Slow wave Sleep	4 weeks	1. Amount of slow wave sleep assessed by standard polysomnographic criteria in 0,75 Hz vs SHAM stimulation during SWS.

Trial Locations

Locations (1)

Charite CCM Neurologie Berlin; 🇩🇪 Berlin, Germany