Impact of Transcranial Slow Oscillating Stimulation on Memory Consolidation During Nocturnal Slow Wave Sleep in Younger, Healthy Subjects
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 22
- 试验地点
- 2
- 主要终点
- Retention of declarative memories after 0.75 Hz stimulation during SWS, vs after sham stimulation during SWS
研究概览
简要总结
The beneficial effect of nocturnal sleep on memory consolidation is well-documented in young, healthy subjects. Especially, periods rich in slow-wave sleep (SWS) have shown a memory enhancing effect on hippocampus-dependent declarative memory. Slow oscillatory activity typically occuring during SWS has been implicated in the consolidation effect. In this study we investigate if the consolidation effect can be amplified by the application of a weak transcranial oscillatory electric current within the frequency range of SWS in humans (0,7-0,8 Hz) during nocturnal SWS.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healthy Subjects
- •unobtrusive, neuropsychological screening
- •age: 18-35 years
- •right handed
排除标准
- •untreated severe internal or psychiatric diseases
- •other severe neurological diseases eg., previous major stroke, brain tumour
- •contraindications to MRI
结局指标
主要结局
Retention of declarative memories after 0.75 Hz stimulation during SWS, vs after sham stimulation during SWS
时间窗: 4 weeks
Retention (difference values between performance at retrieval after sleep minus performance at learning before sleep) between stimulation conditions (0.75 Hz during SWS, vs sham stimulation during SWS) in the declarative memory task.
次要结局
- 4. further memory systems(4 weeks)
- 1. Amount of Slow wave Sleep(4 weeks)
- 2. sleep spindels(4 weeks)
- 3. EEG-correlates(4 weeks)
研究者
Agnes Flöel
Prof. Agnes Flöel, MD
Charite University, Berlin, Germany