A Study to Find Out Whether BI 1015550 Improves Lung Function in People With Progressive Fibrosing Interstitial Lung Diseases (PF-ILDs)
- Registration Number
- NCT05321082
- Lead Sponsor
- Boehringer Ingelheim
- Brief Summary
This study is open to adults with Progressive Fibrosing Interstitial Lung Diseases (PF-ILDs). People who have a form of PF-ILD other than Idiopathic Pulmonary Fibrosis (IPF) can join the study. If they already take nintedanib, they can continue treatment throughout the study.
The purpose of this study is to find out whether a medicine called BI 1015550 helps people with PF-ILD. Participants are put into 3 groups randomly, which means by chance. Participants in 2 groups take different doses of BI 1015550 as tablets twice a day. Participants in the placebo group take placebo tablets twice a day. Placebo tablets look like BI 1015550 tablets but do not contain any medicine.
Participants are in the study for up to two and a half years. During the first year, they visit the study site 10 times. Afterwards, they visit the study site every 3 months. The doctors regularly test participants' lung function. The results of the lung function tests are compared between the groups. The doctors also regularly check participants' health and take note of any unwanted effects.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 1178
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description BI 1015550 high dose BI 1015550 - Placebo Placebo - BI 1015550 low dose BI 1015550 -
- Primary Outcome Measures
Name Time Method Absolute change from baseline in Forced Vital Capacity (FVC) (mL) at Week 52 at baseline, at week 52
- Secondary Outcome Measures
Name Time Method Time to the first occurrence of any of the components of the composite endpoint: time to first acute ILD exacerbation, first hospitalization for respiratory cause, or death (whichever occurs first) over the duration of the trial up to 31 months Key secondary endpoint
Time to hospitalization for respiratory cause or death over the duration of trial up to 31 months Time to death over the duration of trial up to 31 months Absolute change from baseline in Living with Pulmonary Fibrosis (L-PF) Symptoms Dyspnea domain score at Week 52 at baseline, at week 52 The L-PF is a 49-item questionnaire with two modules: Symptoms (28 items) and Impact (21 items).
The Symptom score has three domain scores: dyspnea, cough, and fatigue, as well as a total symptom score.
Items have response options on a five-option numeric rating score with an anchor of 0 "Not at all" to 4 "Extremely", with higher numbers indicating a greater impairment.Time to absolute decline in Forced vital capacity (FVC) % predicted of >10% from baseline or death over the duration of the trial up to 31 months Time to absolute decline in Diffusing Capacity (of Lung) for Carbon Monoxide (DLCO) % predicted of >15% from baseline or death over the duration of the trial up to 31 months Absolute change from baseline in DLCO % predicted at Week 52 at baseline, at week 52 Time to first acute Interstitial Lung Disease (ILD) exacerbation or death over the duration of trial up to 31 months Absolute change from baseline in Living with Pulmonary Fibrosis (L-PF) Symptoms Fatigue domain score at Week 52 at baseline, at week 52 The L-PF is a 44-item questionnaire divided into two modules: Symptoms (23 items) and Impacts (21 items).
The Symptoms module assesses shortness of breath, cough and fatigue in the past 24 hours.
Items have response options on a five-option numeric rating score with an anchor of 0 "Not at all" to 4 "Extremely", with higher numbers indicating a greater impairment.Absolute change from baseline in FVC % predicted at Week 52 at baseline, at week 52 Absolute change from baseline in Living with Pulmonary Fibrosis (L-PF) Symptoms Cough domain score at Week 52 at baseline, at week 52 The L-PF is a 44-item questionnaire divided into two modules: Symptoms (23 items) and Impacts (21 items).
The Symptoms module assesses shortness of breath, cough and fatigue in the past 24 hours.
Items have response options on a five-option numeric rating score with an anchor of 0 "Not at all" to 4 "Extremely", with higher numbers indicating a greater impairment.
Trial Locations
- Locations (403)
HOP Louis Pradel
🇫🇷Bron, France
HOP CHU Caen
🇫🇷Caen, France
HOP François Mitterrand
🇫🇷Dijon, France
HOP Michallon
🇫🇷La Tronche, France
INS Coeur Poumon
🇫🇷Lille, France
HOP Nord
🇫🇷Marseille, France
HOP Arnaud de Villeneuve
🇫🇷Montpellier, France
HOP Pasteur
🇫🇷Nice, France
HOP Bichat
🇫🇷Paris, France
HOP Charles Nicolle
🇫🇷Rouen, France
Klinikum der Universität München AÖR
🇩🇪München, Germany
Johns Hopkins Hospital
🇺🇸Baltimore, Maryland, United States
Klinikum Nürnberg
🇩🇪Nürnberg, Germany
Krankenhaus Bethanien gGmbH
🇩🇪Solingen, Germany
Helios Hanseklinikum Stralsund
🇩🇪Stralsund, Germany
Fondazione Policlinico Universitario A. Gemelli IRCCS
🇮🇹Roma, Italy
A.O.U. Senese Policlinico Santa Maria alle Scotte
🇮🇹Siena, Italy
Ospedali Riuniti di Ancona
🇮🇹Torrette Di Ancona (Ancona), Italy
University of Alabama at Birmingham
🇺🇸Birmingham, Alabama, United States
University of Arizona
🇺🇸Tucson, Arizona, United States
University of Southern California
🇺🇸Los Angeles, California, United States
Cedars-Sinai Medical Center
🇺🇸Los Angeles, California, United States
University of California Los Angeles
🇺🇸Los Angeles, California, United States
University of California Davis
🇺🇸Sacramento, California, United States
National Jewish Health
🇺🇸Denver, Colorado, United States
Yale University School of Medicine
🇺🇸New Haven, Connecticut, United States
Christiana Hospital
🇺🇸Newark, Delaware, United States
St. Francis Medical Institute
🇺🇸Clearwater, Florida, United States
University of Florida Health Shands Hospital
🇺🇸Gainesville, Florida, United States
Clinical Research Specialists LLC
🇺🇸Kissimmee, Florida, United States
Advanced Pulmonary Research Institute
🇺🇸Loxahatchee Groves, Florida, United States
Destin Pulmonary Critical Care
🇺🇸Santa Rosa Beach, Florida, United States
Piedmont Physicians Pulmonary & Sleep Medicine of Buckhead
🇺🇸Atlanta, Georgia, United States
The Emory Clinic
🇺🇸Atlanta, Georgia, United States
Evanston Hospital Pulmonary Clinic
🇺🇸Evanston, Illinois, United States
University of Kansas Medical Center
🇺🇸Kansas City, Kansas, United States
Tulane University Hospital and Clinic
🇺🇸New Orleans, Louisiana, United States
Ospedale di Cattinara
🇮🇹Trieste, Italy
Massachusetts General Hospital
🇺🇸Boston, Massachusetts, United States
Brigham and Women's Hospital
🇺🇸Boston, Massachusetts, United States
St. Elizabeth's Medical Center
🇺🇸Boston, Massachusetts, United States
Beth Israel Deaconess Medical Center
🇺🇸Boston, Massachusetts, United States
Infinity Medical Research
🇺🇸North Dartmouth, Massachusetts, United States
University of Michigan Health System
🇺🇸Ann Arbor, Michigan, United States
Beaumont Health
🇺🇸Royal Oak, Michigan, United States
University of Minnesota
🇺🇸Minneapolis, Minnesota, United States
Mayo Clinic, Rochester
🇺🇸Rochester, Minnesota, United States
Washington University School of Medicine
🇺🇸Saint Louis, Missouri, United States
University of Nebraska Medical Center
🇺🇸Omaha, Nebraska, United States
Renown Regional Medical Center
🇺🇸Reno, Nevada, United States
Stony Brook University Medical Center
🇺🇸Commack, New York, United States
Lenox Hill Hospital
🇺🇸New York, New York, United States
Columbia University Medical Center-New York Presbyterian Hospital
🇺🇸New York, New York, United States
NewYork-Presbyterian/Weill Cornell Medical Center
🇺🇸New York, New York, United States
Duke University Medical Center
🇺🇸Durham, North Carolina, United States
Southeastern Research Center-Winston-Salem-61365
🇺🇸Winston-Salem, North Carolina, United States
University of Cincinnati
🇺🇸Cincinnati, Ohio, United States
Cleveland Clinic
🇺🇸Cleveland, Ohio, United States
The Ohio State University Wexner Medical Center
🇺🇸Columbus, Ohio, United States
The Oregon Clinic
🇺🇸Portland, Oregon, United States
University of Pennsylvania
🇺🇸Philadelphia, Pennsylvania, United States
Temple University Hospital
🇺🇸Philadelphia, Pennsylvania, United States
Tosei General Hospital
🇯🇵Aichi, Seto, Japan
APRILLUS-Asistencia e Investigacion
🇦🇷Ciudad Autonoma Buenos Aires, Argentina
National University Hospital-Singapore-42005
🇸🇬Singapore, Singapore
Hospital de Galdakao
🇪🇸Galdakao, Spain
Jefferson Health Honickman Center
🇺🇸Philadelphia, Pennsylvania, United States
Infinity Medical Research, Inc.
🇺🇸East Providence, Rhode Island, United States
Lowcountry Lung and Critical Care
🇺🇸Charleston, South Carolina, United States
Allegheny General Hospital
🇺🇸Pittsburgh, Pennsylvania, United States
Clinical Trials Center of Middle Tennessee, LLC
🇺🇸Franklin, Tennessee, United States
Vanderbilt University Medical Center - Vanderbilt Lung Institute at 100 Oaks
🇺🇸Nashville, Tennessee, United States
Baylor University Medical Center
🇺🇸Dallas, Texas, United States
Premier Pulmonary Critical Care and Sleep Medicine
🇺🇸Denison, Texas, United States
University of Vermont
🇺🇸Burlington, Vermont, United States
Virginia Mason Medical Center
🇺🇸Seattle, Washington, United States
UT Health San Antonio
🇺🇸San Antonio, Texas, United States
Intermountain Medical Center-Murray-69497
🇺🇸Murray, Utah, United States
University of Utah Health Sciences Center
🇺🇸Salt Lake City, Utah, United States
Inova Fairfax Hospital
🇺🇸Falls Church, Virginia, United States
Centro de Investigaciones Metabolicas (CINME)-C.A.B.A-61553
🇦🇷C.a.b.a, Argentina
CEMER-Centro Medico De Enfermedades Respiratorias
🇦🇷Florida, Argentina
University of Wisconsin
🇺🇸Madison, Wisconsin, United States
CEDIC - Centro de Investigacion Clinica
🇦🇷Caba, Argentina
Hospital Italiano de Buenos Aires
🇦🇷Caba, Argentina
Instituto Ave Pulmo
🇦🇷Mar del Plata, Argentina
INSARES
🇦🇷Mendoza, Argentina
Centro Respiratorio de Quilmes
🇦🇷Quilmes, Argentina
Consultorios Médicos del Buen Ayre
🇦🇷Capital Federal, Argentina
Instituto Médico de la Fundación Estudios Clínicos
🇦🇷Rosario, Argentina
Royal Prince Alfred Hospital
🇦🇺Camperdown, Sydney, New South Wales, Australia
Macquarie University
🇦🇺Macquarie Park, New South Wales, Australia
Westmead Hospital
🇦🇺Westmead, New South Wales, Australia
Lung Research Queensland
🇦🇺Chermside, Queensland, Australia
The Prince Charles Hospital
🇦🇺Chermside, Queensland, Australia
Mater Hospital Brisbane
🇦🇺South Brisbane, Queensland, Australia
ULB Hopital Erasme
🇧🇪Bruxelles, Belgium
Canberra Hospital
🇦🇺Garran, Australian Capital Territory, Australia
Brussels - UNIV Saint-Luc
🇧🇪Bruxelles, Belgium
Royal Adelaide Hospital
🇦🇺Adelaide, South Australia, Australia
Lung Research Victoria
🇦🇺Footscray, Victoria, Australia
Austin Hospital
🇦🇺Heidelberg, Victoria, Australia
The Alfred Hospital
🇦🇺Melbourne, Victoria, Australia
Fiona Stanley Hospital
🇦🇺Murdoch, Western Australia, Australia
Trialswest
🇦🇺Spearwood, Western Australia, Australia
Medical University of Graz State Hospital - University Hospital Graz
🇦🇹Graz, Austria
LKH Klagenfurt am Woerthersee
🇦🇹Klagenfurt Am Woerthersee, Austria
Krems University Hospital
🇦🇹Krems, Austria
Hospital Elisabethinen Linz
🇦🇹Linz, Austria
LKH Salzburg University Hospital
🇦🇹Salzburg, Austria
AKH - Medical University of Vienna
🇦🇹Vienna, Austria
Standort Penzing der Klinik Ottakring
🇦🇹Vienna, Austria
Clinic Floridsdorf
🇦🇹Vienna, Austria
Klinikum Wels - Grieskirchen GmbH
🇦🇹Wels, Austria
Ziekenhuis Netwerk Antwerpen (ZNA) - Campus Middelheim
🇧🇪Antwerpen, Belgium
Zhejiang Hospital
🇨🇳Hangzhou, China
UNIV UZ Gent
🇧🇪Gent, Belgium
UZ Leuven
🇧🇪Leuven, Belgium
Centre Hospitalier Universitaire de Liège
🇧🇪Liège, Belgium
Yvoir - UNIV UCL de Mont-Godinne
🇧🇪Yvoir, Belgium
Serviços Medicos Respirar Sul Fluminense
🇧🇷Barra Mansa, Brazil
Hospital das Clinicas da Universidade Federal HC-UFMG
🇧🇷Belo Horizonte,Minas Gerais, Brazil
Edumed - Educacao e Saude SA
🇧🇷Curitiba, Brazil
CLARE - Clinica de Pneumologia
🇧🇷Goiania, Brazil
Hospital Nossa Senhora da Conceição
🇧🇷Porto Alegre - RS, Brazil
Irmandade da Santa Casa de Misericórdia de Porto Alegre
🇧🇷Porto Alegre, Brazil
Instituto D´Or de Pesquisa e Ensino - Bahia
🇧🇷Salvador, Brazil
Faculdade de Medicina do ABC
🇧🇷Santo André, Brazil
Hospital Alemao Oswaldo Cruz
🇧🇷Sao Paulo, Brazil
CEMEC - Centro Multidisciplinar de Estudos Clínicos
🇧🇷São Bernardo do Campo, Brazil
Hospital das Clinicas da FMUSP
🇧🇷São Paulo, Brazil
Kelowna Respirology & Allergy Research
🇨🇦Kelowna, British Columbia, Canada
Vancouver General Hospital
🇨🇦Vancouver, British Columbia, Canada
St. Paul's Hospital (Vancouver)
🇨🇦Vancouver, British Columbia, Canada
St. Joseph's Healthcare Hamilton
🇨🇦Hamilton, Ontario, Canada
Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine
🇨🇳Hangzhou, China
Dr. Georges-L.-Dumont University Hospital Centre
🇨🇦Moncton, New Brunswick, Canada
Dr. Syed Anees Medicine Professional Corporation
🇨🇦Windsor, Ontario, Canada
Centre Hospitalier de l'Universite de Montreal (CHUM)
🇨🇦Montreal, Quebec, Canada
McGill University Health Centre (MUHC)
🇨🇦Montreal, Quebec, Canada
CIC Mauricie Inc.
🇨🇦Trois-Rivieres, Quebec, Canada
Royal University Hospital (Saskatoon)
🇨🇦Saskatoon, Saskatchewan, Canada
IUCPQ (Laval University)
🇨🇦Quebec, Canada
Instituto Nacional del Tórax
🇨🇱Providencia, Santiago De Chile, Chile
Wuhan Union Hospital
🇨🇳Wuhan, China
Centro de Investigación del Maule
🇨🇱Talca, Chile
Tongji Hospital Affiliated Tongji Medical College Huazhong University of S & T
🇨🇳Wuhan, China
Beijing Chao-Yang Hospital
🇨🇳Beijing, China
China-Japan Friendship Hospital
🇨🇳Beijing, China
Peking Union Medical College Hospital
🇨🇳Beijing, China
Chinese PLA General Hospital
🇨🇳Beijing, China
The Second Xiangya Hospital Of Central South University
🇨🇳Changsha, China
West China Hospital
🇨🇳Chengdu, China
Guangdong Provincial People's Hospital
🇨🇳Guangzhou, China
First Affiliated Hospital of Guangzhou Medical University
🇨🇳Guangzhou, China
NanFang Hosptial
🇨🇳Guangzhou, China
Hangzhou First People's Hospital
🇨🇳Hangzhou, China
The Second Affiliated Hospital Zhejiang University School of Medicine
🇨🇳Hangzhou, China
HOP de la Cavale Blanche
🇫🇷Brest, France
Anhui Provincial Hospital
🇨🇳Hefei, China
The Affiliated Hospital of Inner Mongolia Medical University
🇨🇳Hohhot, China
The First hospital of Jiaxing
🇨🇳Jiaxing, China
Jinhua Municipal Central Hospital
🇨🇳Jinhua, China
Nanjing Drum Tower Hospital
🇨🇳Nanjing, China
Ningbo Medical Center Lihuili Hospital
🇨🇳Ningbo, China
The First Affiliated Hospital of Ningbo University
🇨🇳Ningbo, China
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
🇨🇳Shanghai, China
Shanghai Chest Hospital
🇨🇳Shanghai, China
Zhongshan Hospital Affiliated to Fudan University
🇨🇳Shanghai, China
Huadong Hospital affiliated to Fudan University
🇨🇳Shanghai, China
Shanghai Pulmonary Hospital
🇨🇳Shanghai, China
China Shenyang Chest Hospital
🇨🇳Shenyang, China
Shenzhen People's Hospital
🇨🇳Shenzhen, China
The University of Hong Kong-Shenzhen Hospital
🇨🇳Shenzhen, China
People's Hospital of Sichuan Province
🇨🇳Sichuan, China
The First Affiliated Hospital of Soochow University
🇨🇳Suzhou, China
Tianjin Medical University General Hospital
🇨🇳Tianjin, China
The First Affiliated Hospital of Wenzhou Med College
🇨🇳Wenxzhou, China
Renmin Hospital of Wuhan University
🇨🇳Wuhan, China
Wuxi People's Hospital
🇨🇳Wuxi, China
Second Affiliated Hospital of Xi'an JiaoTong University
🇨🇳Xi'an, China
Affiliated Hospital, Xuzhou Medical college
🇨🇳Xuzhou, China
Yichang NO.1 People's Hospital
🇨🇳Yichang, China
General Hospital of Ningxia Medical University
🇨🇳Yinchuan, China
Yuncheng Central Hospital
🇨🇳Yuncheng, China
University hospital center Zagreb
🇭🇷Zagreb, Croatia
University Hospital Dubrava
🇭🇷Zagreb, Croatia
Solmed Polyclinic
🇭🇷Zagreb, Croatia
Thomayer University Hospital
🇨🇿Praha 4, Czechia
Herlev and Gentofte Hospital
🇩🇰Hellerup, Denmark
Odense University Hospital
🇩🇰Odense, Denmark
North Estonia Medical Centre Foundation, Tallinn
🇪🇪Tallinn, Estonia
HYKS Keuhkosairauksien tutkimusyksikkö
🇫🇮Helsinki, Finland
Oulun yliopistollinen keskussairaala
🇫🇮Oulu, Finland
Tampere University Hospital
🇫🇮Tampere, Finland
TYKS
🇫🇮Turku, Finland
HOP d'Angers
🇫🇷Angers, France
HOP Avicenne
🇫🇷Bobigny, France
HOP Nord Laennec
🇫🇷Nantes Cedex 01, France
HOP Européen G. Pompidou
🇫🇷Paris, France
Hospital Universitari de Girona Doctor Josep Trueta
🇪🇸Girona, Spain
HOP Haut-Lévêque
🇫🇷Pessac, France
HOP Robert Debré
🇫🇷Reims, France
HOP Larrey
🇫🇷Toulouse, France
HOP Bretonneau
🇫🇷Tours, France
National Center for Tuberculosis and Lung Diseases, Tbilisi
🇬🇪Tbilisi, Georgia
HOP Pontchaillou
🇫🇷Rennes, France
HOP Civil
🇫🇷Strasbourg, France
HOP Foch
🇫🇷Suresnes, France
LLC Diacor
🇬🇪Tbilisi, Georgia
Velocity Clinical Research Germany GmbH-Ahrensburg-69816
🇩🇪Ahrensburg, Germany
Universitätsklinikum Bonn AöR
🇩🇪Bonn, Germany
Westfälische Wilhelms-Universität Münster
🇩🇪Münster, Germany
CIMS Studienzentrum Bamberg GmbH
🇩🇪Bamberg, Germany
Vivantes Netzwerk für Gesundheit GmbH
🇩🇪Berlin, Germany
Klinikum Chemnitz gGmbH
🇩🇪Chemnitz, Germany
Fachkrankenhaus Coswig GmbH
🇩🇪Coswig, Germany
Ruhrlandklinik, Westdeutsches Lungenzentrum am Universitätsklinikum Essen gGmbH
🇩🇪Essen, Germany
Universitätsklinikum Hamburg, Eppendorf
🇩🇪Hamburg, Germany
Klinikum Region Hannover GmbH
🇩🇪Hannover, Germany
Medizinische Hochschule Hannover
🇩🇪Hannover, Germany
Thoraxklinik-Heidelberg gGmbH am Universitätsklinikum Heidelberg
🇩🇪Heidelberg, Germany
Lungenklinik Hemer
🇩🇪Hemer, Germany
Lungenfachklinik Immenhausen
🇩🇪Immenhausen, Germany
Klinikum Konstanz
🇩🇪Konstanz, Germany
Robert Bosch Gesellschaft für medizinische Forschung mbH
🇩🇪Stuttgart, Germany
Universitätsklinikum Tübingen
🇩🇪Tübingen, Germany
General Hospital of Athens "Laiko"
🇬🇷Athens, Greece
Univ. Gen. Hosp. of Ioannina
🇬🇷Ioannina, Greece
Univ. Gen. Hosp. of Patras
🇬🇷Patras, Greece
General Hospital of Thessaloniki "Hippokrateio"
🇬🇷Thessaloniki, Greece
Hospital of Heraklion (PAGNI)
🇬🇷Voutes, Greece
Semmelweis University
🇭🇺Budapest, Hungary
Koranyi National Institute For Pulmonolgy
🇭🇺Budapest, Hungary
University of Debrecen Clinical Centre
🇭🇺Debrecen, Hungary
Hindustan Hospital
🇮🇳Coimbatore, India
Bhatia Hospital
🇮🇳Mumbai, India
P.D. Hinduja National Hospital
🇮🇳Mumbai, India
Jehangir Clinical Development Centre Pvt. Ltd.
🇮🇳Pune, India
Mater Misericordiae University Hospital
🇮🇪Dublin, Ireland
Soroka Univ. Medical Center
🇮🇱Beer Sheva, Israel
Shamir Medical Center (Assaf Harofeh)
🇮🇱Beer Yaakov, Israel
Lady Davis Carmel Medical Center
🇮🇱Haifa, Israel
Shaare Zedek Medical Center, Jerusalem 91031
🇮🇱Jerusalem, Israel
Sourasky Medical Center
🇮🇱Tel Aviv, Israel
ASST degli Spedali Civili di Brescia
🇮🇹Brescia, Italy
A.O.U. Policlinico Vittorio Emanuele
🇮🇹Catania, Italy
A. O. Universitaria Careggi
🇮🇹Firenze, Italy
Ospedale Colonnello D Avanzo
🇮🇹Foggia, Italy
Ospedale G.B. Morgagni
🇮🇹Forli', Italy
Ospedale San Paolo-MILANO-18793
🇮🇹Milano, Italy
Ospedale Classificato San Giuseppe
🇮🇹Milano, Italy
Azienda Ospedaliera Policlinico di Modena
🇮🇹Modena, Italy
A.O. San Gerardo di Monza
🇮🇹Monza, Italy
Osp. dei Colli Monaldi
🇮🇹Napoli, Italy
Azienda Ospedaliera Universitaria di Padova
🇮🇹Padova, Italy
Pol. Universitario Tor Vergata
🇮🇹Roma, Italy
Fujita Health University Hospital
🇯🇵Aichi, Toyoake, Japan
National Hospital Organization Kyushu Medical Center
🇯🇵Fukuoka, Fukuoka, Japan
Hokkaido University Hospital
🇯🇵Hokkaido, Sapporo, Japan
Kobe City Medical Center General Hospital
🇯🇵Hyogo, Kobe, Japan
Kobe City Hospital Organization Kobe City Medical Center West Hospital
🇯🇵Hyogo, Kobe, Japan
Kagawa University Hospital
🇯🇵Kagawa, Kita-gun, Japan
Kanagawa Cardiovascular and Respiratory Center
🇯🇵Kanagawa, Yokohama, Japan
University of Fukui Hospital
🇯🇵Fukui, Yoshida-gun, Japan
Hiroshima Prefectural Hospital
🇯🇵Hiroshima, Hiroshima, Japan
National Hospital Organization Himeji Medical Center
🇯🇵Hyogo, Himeji, Japan
Kyushu University Hospital
🇯🇵Fukuoka, Fukuoka, Japan
Sapporo Medical University Hospital
🇯🇵Hokkaido, Sapporo, Japan
Aso Co.,Ltd Iizuka Hospital
🇯🇵Fukuoka, Iizuka, Japan
Kurume University Hospital
🇯🇵Fukuoka, Kurume, Japan
Tsuboi Hospital
🇯🇵Fukushima, Koriyama, Japan
Saiseikai Kumamoto Hospital
🇯🇵Kumamoto, Kumamoto, Japan
Nagasaki University Hospital
🇯🇵Nagasaki, Nagasaki, Japan
National Hospital Organization Kinki-Chuo Chest Medical Center
🇯🇵Osaka, Sakai, Japan
Hospital of the University of Occupational and Environmental Health
🇯🇵Fukuoka, Kitakyushu, Japan
Fukushima Medical University Hospital
🇯🇵Fukushima, Fukushima, Japan
Kyoto University Hospital
🇯🇵Kyoto, Kyoto, Japan
Tohoku University Hospital
🇯🇵Miyagi, Sendai, Japan
Osaka Medical and Pharmaceutical University Hospital
🇯🇵Osaka, Takatsuki, Japan
Saitama Red Cross Hospital
🇯🇵Saitama, Saitama, Japan
Jichi Medical University Hospital
🇯🇵Tochigi, Shimotsuke, Japan
Kindai University Hospital
🇯🇵Osaka, Osakasayama, Japan
Hamamatsu University Hospital
🇯🇵Shizuoka, Hamamatsu, Japan
Juntendo University Hospital
🇯🇵Tokyo, Bunkyo-ku, Japan
Nippon Medical School Hospital
🇯🇵Tokyo, Bunkyo-ku, Japan
Toranomon Hospital
🇯🇵Tokyo, Minato-ku, Japan
Kyorin University Hospital
🇯🇵Tokyo, Mitaka, Japan
Toho University Omori Medical Center
🇯🇵Tokyo, Ota-ku, Japan
Tokushima University Hospital
🇯🇵Tokushima, Tokushima, Japan
Institute of Science Tokyo Hospital
🇯🇵Tokyo, Bunkyo-ku, Japan
Tokyo Medical University Hospital
🇯🇵Tokyo, Shinjuku-ku, Japan
Keio University Hospital
🇯🇵Tokyo, Shinjuku-ku, Japan
National Center for Global Health and Medicine
🇯🇵Tokyo, Shinjuku-ku, Japan
Wakayama Medical University Hospital
🇯🇵Wakayama, Wakayama, Japan
The Catholic University of Korea, Bucheon St.Mary's Hospital
🇰🇷Bucheon, Korea, Republic of
Seoul National University Bundang Hospital
🇰🇷Seongnam, Korea, Republic of
Kyung Hee University Hospital
🇰🇷Seoul, Korea, Republic of
Seoul National University Hospital
🇰🇷Seoul, Korea, Republic of
Severance Hospital
🇰🇷Seoul, Korea, Republic of
Soonchunhyang University Hospital Seoul
🇰🇷Seoul, Korea, Republic of
Asan Medical Center
🇰🇷Seoul, Korea, Republic of
Samsung Medical Center
🇰🇷Seoul, Korea, Republic of
Hospital Sultan Idris Shah Serdang
🇲🇾Kajang, Malaysia
Institut Perubatan Respiratori
🇲🇾Kuala Lumpur, Malaysia
Sarawak General Hospital
🇲🇾Kuching, Malaysia
Hospital Pulau Pinang-Pulau Pinang-21953
🇲🇾Pulau Pinang, Malaysia
Centro Respiratorio de Mexico
🇲🇽Cdmx, Mexico
Centro de Investigacion Integral MEDIVEST S.C
🇲🇽Chihuahua, Mexico
Soltmed Smo
🇲🇽Ciudad de Mexico, Mexico
CREPID Aire y Salud Integral
🇲🇽Coyoacan, Mexico
Centro de Investigacion Farmacologica del Bajío, S.C.
🇲🇽Guanajuato, Mexico
Centro de Prevención y Rehabilitación de Enfermedades Pulmon
🇲🇽Monterrey, Mexico
Oaxaca Site Management Organization, S.C.
🇲🇽Oaxaca, Mexico
Asociación Mexicana para la Investigacion Clínica, A.C(AMIC)
🇲🇽Pachuca, Mexico
Zuyderland Medisch Centrum
🇳🇱Heerlen, Netherlands
Leids Universitair Medisch Centrum (LUMC)
🇳🇱Leiden, Netherlands
St. Antonius ziekenhuis, locatie Nieuwegein
🇳🇱Nieuwegein, Netherlands
Erasmus Medisch Centrum-ROTTERDAM-50697
🇳🇱Rotterdam, Netherlands
Waikato Hospital
🇳🇿Hamilton, New Zealand
Greenlane Clinical Centre
🇳🇿One Tree Hill, Auckland, New Zealand
Middlemore Clinical Trials
🇳🇿Papatoetoe, New Zealand
Tauranga Hospital
🇳🇿Tauranga South, New Zealand
Haukeland Universitetssykehus
🇳🇴Bergen, Norway
Akershus Universitetssykehus HF
🇳🇴Lørenskog, Norway
Oslo Universitetssykehus HF, Rikshospitalet
🇳🇴Oslo, Norway
University Clinical Center, Gdansk
🇵🇱Gdansk, Poland
Leszek Giec Upper-Silesian Med.Cent.Silesian Med.Univ.
🇵🇱Katowice, Poland
Alergopneuma Medical Center
🇵🇱Swidnik, Poland
Nat.Instit.of Tuberculosis&LungDiseases,Outpat.Clin,warszawa
🇵🇱Warsaw, Poland
University Clinical Center of the Medical University of Warsaw
🇵🇱Warsaw, Poland
ULS Braga
🇵🇹Braga, Portugal
ULS de São José, E.P.E.
🇵🇹Lisboa, Portugal
USLM, EPE - Hospital Pedro Hispano
🇵🇹Matosinhos, Portugal
ULS de Gaia/Espinho, EPE
🇵🇹Vila Nova de Gaia, Portugal
Allianze Pulmonary Research LLC
🇵🇷Guaynabo, Puerto Rico
King Fahad Specialist Hospital - Research Center
🇸🇦Dammam, Saudi Arabia
King Faisal Specialist Hospital and Research Center
🇸🇦Riyadh, Saudi Arabia
King Abdullah International Medical Research Center
🇸🇦Riyadh, Saudi Arabia
University Clinical Center of Serbia
🇷🇸Belgrade, Serbia
University Clinical Center of Kragujevac
🇷🇸Kragujevac, Serbia
Institute for Pulmonary Diseases of Vojvodina
🇷🇸Sremska Kamenica, Serbia
Melomed Gatesville Hospital
🇿🇦Cape Town, South Africa
University Clinical Center Nis
🇷🇸Nis, Serbia
Singapore General Hospital
🇸🇬Singapore, Singapore
KwaPhila Health Solutions
🇿🇦Durban, South Africa
Hospital Golnik - Univ. Clinic of Pulmonary and Allergic Diseases
🇸🇮Golnik, Slovenia
Busamed Paardevlei Private Hospital
🇿🇦Cape Town, South Africa
Hospital General Universitario de Alicante
🇪🇸Alicante, Spain
Hospital del Mar
🇪🇸Barcelona, Spain
Hospital Vall d'Hebron
🇪🇸Barcelona, Spain
Hospital Clínic de Barcelona
🇪🇸Barcelona, Spain
Hospital de Basurto
🇪🇸Bilbao, Spain
Hospital Universitario Virgen de la Arrixaca
🇪🇸El Palmar, Spain
Hospital Universitario Virgen de las Nieves
🇪🇸Granada, Spain
Hospital de Bellvitge
🇪🇸L'Hospitalet de Llobregat, Spain
Hospital La Princesa
🇪🇸Madrid, Spain
Hospital General Universitario Gregorio Marañón
🇪🇸Madrid, Spain
Hospital Universitario Infanta Leonor
🇪🇸Madrid, Spain
Hospital Ramón y Cajal
🇪🇸Madrid, Spain
Hospital Universitario 12 de Octubre
🇪🇸Madrid, Spain
Hospital Virgen de la Victoria
🇪🇸Malaga, Spain
Hospital Central de Asturias
🇪🇸Oviedo, Spain
Hospital Quirónsalud Madrid
🇪🇸Pozuelo de Alarcón, Spain
Hospital Universitario Marqués de Valdecilla
🇪🇸Santander, Spain
Hospital Clínico de Santiago
🇪🇸Santiago de Compostela, Spain
Hospital Virgen del Rocío
🇪🇸Sevilla, Spain
Hospital Nuestra Señora de Valme
🇪🇸Sevilla, Spain
Akademiska sjukhuset
🇸🇪Uppsala, Sweden
University Hospital Basel
🇨🇭Basel, Switzerland
University Hospital Bern/Inselspital Bern
🇨🇭Bern, Switzerland
Chang-Hua Christian Hospital
🇨🇳Changhua, Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital
🇨🇳Kaohsiung, Taiwan
Kaohsiung Chang Gung Memorial Hospital
🇨🇳Kaohsiung, Taiwan
China Medical University Hospital
🇨🇳Taichung, Taiwan
Taichung Veterans General Hospital
🇨🇳Taichung, Taiwan
NCKUH
🇨🇳Tainan, Taiwan
Taipei Veterans General Hospital
🇨🇳Taipei, Taiwan
Siriraj Hospital
🇹🇭Bangkok Noi, Thailand
Songklanagarind Hospital
🇹🇭Hat Yai, Thailand
Srinagarind Hospital
🇹🇭Khon Kaen, Thailand
Central Chest Institute of Thailand
🇹🇭Muang, Thailand
Maharat Nakhonchiangmai Hospital
🇹🇭Muang, Thailand
Ramathibodi Hospital
🇹🇭Ratchatewi, Thailand
Gulhane Training and Research Hospital
🇹🇷Ankara, Turkey
Ankara Universitesi Tip Fakultesi
🇹🇷Ankara, Turkey
Akdeniz Universitesi Tip Fakultesi -ANTALYA-33606
🇹🇷Antalya, Turkey
Uludag Universitesi Tip Fakultesi
🇹🇷Bursa, Turkey
Istanbul Universitesi Istanbul Tip Fakultesi
🇹🇷Istanbul, Turkey
Gazi Universitesi Tip Fakultesi
🇹🇷Yenimahalle/ANKARA, Turkey
Aberdeen Royal Infirmary
🇬🇧Aberdeen, United Kingdom
Queen Elizabeth Hospital Birmingham
🇬🇧Birmingham, United Kingdom
Southmead Hospital
🇬🇧Bristol, United Kingdom
Royal Infirmary of Edinburgh
🇬🇧Edinburgh, United Kingdom
Royal Devon and Exeter Hospital, Wonford
🇬🇧Exeter, United Kingdom
Royal Lancaster Infirmary
🇬🇧Lancaster, United Kingdom
St James's University Hospital
🇬🇧Leeds, United Kingdom
Altnagelvin Area Hospital
🇬🇧Londonderry, United Kingdom
Guy's Hospital
🇬🇧London, United Kingdom
Royal Brompton Hospital
🇬🇧London, United Kingdom
Wythenshawe Hospital
🇬🇧Manchester, United Kingdom
Churchill Hospital
🇬🇧Oxford, United Kingdom
Southampton General Hospital
🇬🇧Southampton, United Kingdom