Serum FGF-23 and Vitamin D Deficiency

Completed

• Conditions: Osteomalacia

• Registration Number: NCT01102751
• Lead Sponsor: Istanbul University

Brief Summary

We aimed to determine the effect of vitamin D replacement therapy on serum FGF-23 concentrations in vitamin D deficient women and to compare the FGF-23 concentrations of vitamin D deficient patients with healthy subjects and patients with genetically-determined hypophosphatemic rickets.

Detailed Description

Study group was composed of vitamin D deficient females (n =18, mean age 29.1±9.9 yrs), vitamin D sufficient healthy females (control group; n = 19, mean age 28.5±5.2 yrs) and patients with genetically-determined hypophosphatemic rickets (n=13, mean age 26.5±15.1 yrs). Groups were compared for serum FGF-23, 1,25 dihydroxy vitamin D3, calcium, phosphate, bone turnover markers, intact parathyroid hormone and urinary excretion of calcium and phosphate. Vitamin D deficient group was re-evaluated after a standard treatment regimen.

Study Timeline

• Status Verified: 2009-08
• Study First Submitted: 2010-04-12
• Study First Submitted QC: 2010-04-12
• Last Update Submitted: 2010-04-12
• Study First Posted: 2010-04-13
• Last Update Posted: 2010-04-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• Serum 25OHD Vitamin <30 ng/mL for group 1
• Serum 25OHD Vitamin >30 ng/mL for control group

Exclusion Criteria

• Receiving medication(s) affecting bone metabolism
• History of gastrointestinal disease and malabsorption
• History of renal and liver disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

Istanbul University, Istanbul Faculty of Medicine, Department of Internal Medicine, Division of Endocrinology and Metabolism; 🇹🇷 Istanbul, Turkey