The role of endometrial angiogenesis in patients with bleeding disorders in case of submucous fibroids
Recruiting
- Conditions
- 1001332610038595Fibroidleiomyomata
- Registration Number
- NL-OMON36239
- Lead Sponsor
- Vrije Universiteit Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 50
Inclusion Criteria
Premenopausal women, aged above18 years, with a regular menstrual cycle planned for a transcervical hysteroscopic resection (TCRM) of submucous fibroids.
Exclusion Criteria
Occlusion or embolization of uterine arteries in the history, risk of pelvic inflammatory disease, known endometrioses, cervical cancer or pregnancy.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Differences in histological vascular density (based on CD34/31) in endometrium<br /><br>covering fibroids versus normal endometrium.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Differenes in kwantified VEGF-A, VEGF-B, VEGF-C, FGF, Estradiol receptor,<br /><br>Progesterone receptor expression, kwantified hysteroscopic vascular density<br /><br>(using Narrow Band Imaging). Level of CD34/31 related ki67 expression.<br /><br>The relation between endometrial vascularity index and angiogenic profile in<br /><br>endometrium covering a fibroid with severity of menstrual bleeding (PBAC) and<br /><br>total number of days will be assessed.<br /><br>Potential prognostic parameters: age, cycle day, OC or GnRHa use, fibroid size<br /><br>and level of protrusion (GIS) and vascular indices measured with 3D TV-US will<br /><br>be registered. </p><br>