Immonotyping target tissues of inflammation in Psoriasis and Psoriatic Artritis
- Conditions
- chronic joint inflammation in psoriasis patients100038161002321310011063
- Registration Number
- NL-OMON56005
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 108
All patients 18 years or older with a clinical diagnosis of PsO or PsA
A potential subject who meets any of the following criteria will be excluded
from participation in this study: • Patients, who are not able to provide
informed consent. • History of malignancy • Viral or bacterial infection within
the past 4 weeks • Patients using anticoagulant therapy • Present or previous
use of systemic corticosteroids less than 28 days before enrollment • Present
or previous treatment with any cell depleting therapies, including
investigational agents. • Presence of any disease for which study subjects need
chronic or intermittent immunosuppressive therapy (e.g. prednisolone). •
History of chronic viral infection • Recent (<1 week) bacterial or viral
infection • History of autoimmune disease • Recent (< 4 weeks) vaccination
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>1. Frequencies and phenotype of immune cell populations in peripheral lymph<br /><br>nodes (inguinal LNs), skin and joint tissues in psoriatic artritis and<br /><br>psoriasis<br /><br>2. Differences in immune cell populations profiles (cytokine production,<br /><br>genetic, epigenetic and transcriptional alterations) in peripheral lymph nodes,<br /><br>skin and joint tissues psoriatic artritis and psoriasis</p><br>
- Secondary Outcome Measures
Name Time Method <p>1. Frequency and gene expression profiles of stromal cells in lymph nodes of<br /><br>psoriatic artritis and psoriasis patients<br /><br>2. Frequency and phenotype of immune cells in psoriatic plaque lesions, lymph<br /><br>node and inflamed synovial tissue<br /><br>3. Gene expression profiles in skin/synovial tissue/lymph node tissue in<br /><br>psoriatic artritis and psoriasis patients</p><br>