Brain Perfusion Assessment in the Acute Phase of Migraine Aura

Terminated

• Conditions: Emergencies

• Registration Number: NCT03821584
• Lead Sponsor: Nantes University Hospital

Brief Summary

The aim of the study is to determine the proportion of patients with change in brain perfusion during the acute phase of migraine attack with aura.

Detailed Description

Migraine is a benign and frequent disorder. Migraine aura consists in reversible focal neurological symptoms developing gradually during attack. Its diagnosis relies mainly on patient's history, clinical examination and exclusion of other possible secondary causes to explain transient neurological signs. Thus it can be difficult particularly during first attack or during attack without headache to differentiate migraine aura from transient ischemic stroke. Considering the difference of care management and prognosis, an early distinction of migraine aura based on imaging techniques will have a particular interest. MRI with diffusion, SWI, Flair 2D, ARM 3D TOF, ASL sequences' are routinely performed for the management of acute neurological deficit. Arterial spin labeling (ASL), as a MR perfusion method, will be used to describe brain perfusion during migraine aura. The study hypothesis is that hyperperfusion occurs in brain territories corresponding to the neurological symptoms during migraine aura.

Study Timeline

• Study First Submitted: 2019-01-04
• Study First Submitted QC: 2019-01-28
• Study First Posted: 2019-01-30
• Study Start: 2019-03-01
• Primary Completion: 2021-06-22
• Status Verified: 2021-07
• Study Completion: 2021-07-22
• Last Update Submitted: 2021-09-10
• Last Update Posted: 2021-09-17

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

• Age between greater than or equal to 18
• Able to undergo MRI during migraine aura

Exclusion Criteria

• Pregnant females
• Contraindications towards MRI scanning
• History of epilepsy, psychiatric disease, or any other neurologic disease (brain tumors, stroke..).
• Presence of abnormalities on the MRI that could explain the neurological deficit.
• Adults under guardianship or trusteeship

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Perfusion pattern of concerned brain areas	1 hour	Presence or absence of hypo-hyperperfusion using arterial spin labeling. Visual assessments and comparison between hemispheres

Secondary Outcome Measures

Name	Time	Method
Pattern of perfusion and aura duration	12 month	Change in brain perfusion in relation to neurological deficits (migraine aura) duration.

Trial Locations

Locations (1)

CHU Nantes; 🇫🇷 Nantes, France