The Effect of Amino Acid Supplementation on Skeletal Muscle Protein Turnover Following Endurance Exercise
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 23
- 试验地点
- 4
- 主要终点
- Change in muscle protein synthesis after exercise or exercise with amino acid supplementation.
研究概览
简要总结
The modern warfighter faces numerous physiological challenges including sleep deprivation, sustained intense physical activity, and caloric restriction, the combined effects of which may result in the loss of lean body mass and decreased physical performance. Dietary interventions may help preserve lean body mass and facilitate recovery from periods of intense physical demand. For example, dietary strategies that increase amino acid availability have been shown to stimulate protein synthesis in skeletal muscle following resistance exercise. Because military tasks also incorporate endurance exercise components, studies regarding the effects of increasing dietary amino acids following endurance exercise are warranted. The objectives of this study are to characterize the effect of endurance exercise on protein synthesis and breakdown as well as the ability of an essential amino acid supplement to influence skeletal muscle protein metabolism and its cellular and molecular regulation following endurance exercise.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Men and women aged 18 - 35 years
- •Weight stable
- •Recreationally active with VO2max of 40 - 50 ml/kg/min
- •Refrain from taking any NSAIDS or any aspirin-containing medications
- •Supervisor approval if a federal employee
排除标准
- •Disease or medication that affects macronutrient metabolism and/or the ability to participate in strenuous exercise
- •Allergies to foods or medications (including, but not limited to, lidocaine or phenylalanine) to be utilized in the study
- •Abnormal PT/PTT test or problems with blood clotting
- •Present condition of alcoholism or other substance abuse that compromises exercise capacity
- •Musculoskeletal injuries that compromise the ability to exercise
- •Pregnancy
结局指标
主要结局
Change in muscle protein synthesis after exercise or exercise with amino acid supplementation.
时间窗: An average change over a 210 minute recovery period from a 60 minute endurance exercise session
次要结局
- Change in intracellular signaling after exercise or exercise with amino acid supplementation.(At 30 minutes and 210 minutes after a 60 minute endurance exercise session)