Post-operative pain relief in patients undergoing laparoscopic cholecystectomy under general anaesthesia

Phase 3

Not yet recruiting

• Conditions: Calculus of gallbladder without cholecystitis,

• Registration Number: CTRI/2020/08/027342
• Lead Sponsor: NA

Brief Summary

Post-operativepain after laparoscopic cholecystectomy is avery common complication hinderingearly return of routine activity. In various studies intraperitonealinstillation of local anaesthetics have been shown to be safe, effective andminimally invasive and opioids have shown to have a synergestic effect.Ropivacaine is shown to be more safe and efficacious as compared to other localanaesthetics such as bupivacaine. Similarly, nalbuphine is better than otheropioids due to its mixed action on opioid receptors. Since agonist opioids arenot available with us, the most common drug used for intraoperative analgesiais IV butorphanol. So the purpose of our study is to compare the effect of intraperitonealbutorphanol with intraperitoneal nalbuphine for laparoscopic cholecystectomy.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2020-08-21
• Study Start: 2020-08-25

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• 1.ASA physical status I and II.
• 2.Elective laparoscopic cholecystectomy.

Exclusion Criteria

• 1.Acute cholecystitis.
• 2.Carcinoma Gall bladder.
• 3.Hypersensitivity to study drugs.
• 4.Pregnant females.
• 5.Bleeding disorders.
• 6.Opioid addicts.
• 7.Patient refusal to participate in the study.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To compare the efficacy of intraperitoneal instillation of ropivacaine and butorphanol versus ropivacaine and nalbuphine for post-operative pain relief in patients undergoing laparoscopic cholecystectomy under general anaesthesia.	After extubation of patient till 24 hours.

Secondary Outcome Measures

Name	Time	Method
To compare the timing of first request and frequency of rescue analgesia.	After extubation of patient till 24 hours.

Trial Locations

Locations (1)

SGRDIMSAR; 🇮🇳 Amritsar, PUNJAB, India

SGRDIMSAR

🇮🇳Amritsar, PUNJAB, India

Dr Ruchi Gupta

Principal investigator

9814320805

drruchisgrd@gmail.com