Study of the Effect of Oral Zinc Supplementation on Superoxide Radical Scavengers

Phase 2

Completed

• Conditions: Asthenozoospermia
• Interventions: Dietary Supplement: zinc sulfate

• Registration Number: NCT02217189
• Lead Sponsor: Babylon University

Brief Summary

Although several studies have considered the relationship between infertility and semen super oxide radical scavengers levels, no study on the effects of asthenospermia treatments such as oral zinc supplementation on superoxide radical scavengers activity which are important in fertility of the individual has been reported.

Detailed Description

The present study was conducted to study the effect of zinc supplementation on the quantitative and qualitative characteristics of semen along with superoxide radical scavengers activity in the seminal plasma of asthenospermic patients.

Study Timeline

• Study Start: 2011-07
• Primary Completion: 2012-06
• Study Completion: 2012-07
• Study First Submitted: 2014-08-06
• Study First Submitted QC: 2014-08-13
• Study First Posted: 2014-08-15
• Status Verified: 2017-02
• Last Update Submitted: 2017-02-01
• Last Update Posted: 2017-02-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 120

Inclusion Criteria

• the presence of asthenozoospermia in the semen sample.

Exclusion Criteria

• the absence of endocrinopathy, varicocele, and female factor infertility. Smokers and alcoholic men were excluded from the study because of their recognized high seminal ROS levels and decreased antioxidant levels.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Zinc sulfate	zinc sulfate	60 subfertile (age 32.5±3.23 year) men with asthenozoospermia was treated with zinc sulfate, every participant took two capsules of zinc sulfate per day for three months (each one 220 mg).

Primary Outcome Measures

Name	Time	Method
Oxido-sensitive index level in spermatozoa and seminal plasma.	up to three months.

Secondary Outcome Measures

Name	Time	Method
Volume of semen.	up to three months.
Xanthine oxidase activity in spermatozoa and seminal plasma.	up to three months.
Catalase like activity in spermatozoa and seminal plasma.	up to three months.
Superoxide dismutase activity in spermatozoa and seminal plasma.	up to three months.
Progressive sperm motility percentage.	up to three months
Total normal sperm count.	up to three months.

Trial Locations

Locations (1)

Babylon University; 🇮🇶 Hilla, Babylon, Iraq