Impairment of Reading Ability in Dry Eye Patients
- Conditions
- Dry Eye Syndromes
- Registration Number
- NCT01826812
- Lead Sponsor
- Johns Hopkins University
- Brief Summary
To assess the reading function impairment in patients with dry eye and to assess the effects of reading on the ocular surface.
- Detailed Description
This study is being done to understand how reading is affected in people with dry eye in comparison with healthy controls and what effect reading has on the ocular surface in patients with dry eye.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 200
- age of 50 or greater,
- literacy in English language,
- ability to give informed consent
- binocular vision below 20/25,
- any ocular surgery within the last 3 months,
- mental issues,
- illiteracy,
- language problems which might possibly interfere with reading ability,
- history of taking or current use of topical prescription anti-inflammatory eye drops (including, cyclosporine and steroids as well as any glaucoma eye drops).
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Sustained Silent Reading Speed 30 minutes
- Secondary Outcome Measures
Name Time Method Change in Total Ocular Staining Score (OSS) Before and after 30 minutes reading Ocular staining score (OSS) is sum of the corneal and conjuctival staining scores with a total possible maximum score of 12 for each eye. Corneal staining is graded with a maximum possible fluorescein score of 6 for each cornea (the punctate epithelial erosions grade between 0-3 plus any extra points for modifiers up to 3). Nasal and temporal conjunctiva are graded separately with a score range between 0 and 3 for each area after instillation of lissamine green. An abnormal OSS is defined as being a total score of 3 or more.
Change in Tear Osmolarity Before and after 30 minutes reading Change in Visual Acuity 30 minutes Cytokines Tear samples were collected on the day of the exam. The samples were frozen to be assayed upon completion of the study. Identification of various inflammatory cytokines in tear film of dry eye patients comparing to controls.
Trial Locations
- Locations (1)
The Wilmer Eye Institute, Johns Hopkins University
🇺🇸Baltimore, Maryland, United States
The Wilmer Eye Institute, Johns Hopkins University🇺🇸Baltimore, Maryland, United States